EFFECT OF ACUTE ZINC DEPRIVATION ON PLASMA ZINC AND PLATELET-AGGREGATION IN ADULT MALES
EFFECT OF ACUTE ZINC DEPRIVATION ON PLASMA ZINC AND PLATELET-AGGREGATION IN ADULT MALES
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DOI：
10.1093/ajcn/35.1.113
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发表时间：
1982-01-01
影响因子：
7.1
通讯作者：
ODELL, BL
中科院分区：
文献类型：
--
作者：
GORDON, PR;WOODRUFF, CW;ODELL, BL
鉴于啮齿动物的早期研究结果，本研究旨在探讨人类急性缺锌对血浆锌浓度和血小板对聚集剂的反应的影响。三名成年男子食用以大豆蛋白为主的配方饮食12-14天。在对照期间，日粮中添加锌12 mg/d。在没有补充的情况下，饮食提供了.apprx。锌0.5 mg/3.0Mcal，含锌0.7ppm，植酸盐0.2%。停补锌后，血浆锌迅速下降，第5天降至最低。1例受试者血浆锌浓度有较大的昼夜变化，其中隔夜空腹血锌浓度最高，早餐后即刻下降。当血浆锌低于60ug/dl时，ADP和花生四烯酸引起的血小板聚集功能受损，口服补锌后19h内恢复正常。膳食缺锌可使血浆锌迅速降低，细胞外锌在血小板聚集中起重要作用。
In view of earlier results obtained with rodents, the present study was designed to investigate the effect of acute Zn deprivation in man on plasma Zn concentration and the response of platelets to aggregating agents. Three adult men consumed a formula diet based largely on soybean protein for 12-14 days. During the control period the diet was supplemented with 12 mg Zn/day. Without supplementation the diet supplied .apprx. 0.5 mg Zn/3.0 Mcal; it contained 0.7 ppm Zn, and 0.2% phytate. After removal of the Zn supplement plasma Zn dropped rapidly and reaches a minimum by the 5th day. There was a wide diurnal variation in plasma Zn concentration in 1 subject with the overnight fasting value being the highest and decreasing soon after the morning meal. Platelet aggregation in response to ADP and arachidonate was impaired when plasma Zn was 60 .mu.g/dl or less and was restored to normal within 19 h of oral Zn supplementation. Plasma Zn can be rapidly decreased by dietary Zn deprivation and extracellular Zn plays an important role in platelet aggregation.