Metal-catalyzed regioselective oxy-functionalization of internal alkynes: An entry into ketones, acetals, and spiroketals
Metal-catalyzed regioselective oxy-functionalization of internal alkynes: An entry into ketones, acetals, and spiroketals
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DOI：
10.1021/ol0619819
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发表时间：
2006-10-12
期刊：
影响因子：
5.2
通讯作者：
De Brabander, Jef K.
中科院分区：
文献类型：
--
作者：
Liu, Bo;De Brabander, Jef K.
[图形]铂(II)和一种特殊的阳离子金(I)络合物被鉴定为温和的催化剂，可用于未活化的内部炔醇的室温环异构化或串联氢烷氧基化/缩醛生成。在适当的条件下，5-endo、5-exo、6-endo和6-exo环异构化都是可行的。
[GRAPHICS]Platinum(II) and an unusual cationic gold( I) complex were identified as mild catalysts for the room temperature cycloisomerization or tandem hydroalkoxylation/acetal formation of unactivated internal alkynols. Under the appropriate conditions, 5-endo, 5-exo, 6-endo, and 6-exo cycloisomerization modes are all available.