Dental composites based on hybrid and surface-modified amorphous calcium phosphates
Dental composites based on hybrid and surface-modified amorphous calcium phosphates
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DOI：
10.1016/j.biomaterials.2003.08.001
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发表时间：
2004-03-01
期刊：
影响因子：
14
通讯作者：
Eldelman, N
中科院分区：
文献类型：
--
作者：
Skrtic, D;Antonucci, JM;Eldelman, N
本研究的目的是制备杂化和表面改性的无定形磷酸钙（ACP）作为矿物释放牙科复合材料的填料，并确定是否可以提高复合材料的机械强度而不降低其再矿化潜力。ACP与正硅酸乙酯或氯化氧锆杂化，并用3-甲基丙烯酰氧基丙氧基三甲氧基硅烷（MPTMS）或二甲基丙烯酸氧锆（ZrDMA）进行表面处理。测试了用未改性ACP（u-ACP）、混杂或表面改性ACP填料和光活化的Bis-GMA、TEGDMA和甲基丙烯酸2-羟乙酯（HEMA）（BTH树脂）、Bis-GMA、TEGDMA、HEMA和MPTMS（BTHS树脂）或Bis-GMA、TEGDMA、HEMA和ZrDMA（BTHZ树脂）制备的复合材料的再结晶潜力和双轴弯曲强度（BFS）。从所有复合材料的离子释放显着高于最低所需的磷灰石再沉淀。未填充的聚合物的BFS没有受到浸泡在盐溶液中的不利影响。BTH和BTHS复合材料的BFS在浸泡后恶化。然而，BTHZ复合材料几乎不受暴露于盐溶液的影响。填料杂化导致BTHZ复合材料的BFS（高达24%）的适度但显著的改善。通过FTIR显微光谱分析检测到ACP在磁盘表面上的不均匀分布。这可能是由ACP颗粒的不受控制的聚集引起的，ACP颗粒似乎阻碍了界面填料/树脂相互作用并降低了复合材料的机械强度。(C)2003 Elsevier Ltd.保留所有权利。
The objectives of this study were to prepare hybrid and surface-modified amorphous calcium phosphates (ACPs) as fillers for mineral-releasing dental composites, and determine whether the mechanical strength of the composites could be improved without decreasing their remineralization potential. ACP was hybridized with tetraethoxysilane or zirconyl chloride and surface-treated with 3-methacryloxypropoxytrimethoxy silane (MPTMS) or zirconyl dimethacrylate (ZrDMA). Composites fabricated with unmodified ACP (u-ACP), hybrid or surface-modified ACP filler and photo-activated Bis-GMA, TEGDMA and 2-hydroxyethyl methacrylate (HEMA) (BTH resin), Bis-GMA, TEGDMA, HEMA and MPTMS (BTHS resin) or Bis-GMA, TEGDMA, HEMA and ZrDMA (BTHZ resin) were tested for their remineralizing potential and biaxial flexure strength (BFS). Ion releases from all composites were significantly above the minimum necessary for reprecipitation of apatite. The BFS of unfilled polymers was not adversely affected by immersion in saline solutions. The BFS of BTH and BTHS composites deteriorated upon soaking. However, BTHZ composites were practically unaffected by exposure to saline solutions. Filler hybridization resulted in a modest, but significant, improvement in the BFS (up to 24%) of BTHZ composites. Heterogeneous distribution of the ACP on disk surfaces was detected by the FTIR microspectroscopy analyses. This might have been caused by uncontrolled aggregation of ACP particles that appeared to hinder interfacial filler/resin interactions and diminish the mechanical strength of composites. (C) 2003 Elsevier Ltd. All rights reserved.