Regional alterations in human choroidal thickness in response to short-term monocular hemifield myopic defocus
Regional alterations in human choroidal thickness in response to short-term monocular hemifield myopic defocus
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DOI：
10.1111/opo.12609
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发表时间：
2019-05-01
影响因子：
2.9
通讯作者：
Read, Scott A.
中科院分区：
文献类型：
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作者：
Hoseini-Yazdi, Hosein;Vincent, Stephen J.;Read, Scott A.
目的应用光学相干断层扫描（OCT）技术研究短期半视野近视离焦后人脉络膜厚度的局部变化。方法25例健康青年（平均年龄26 ± 5岁），右眼遮盖，左眼中央26视野分别暴露于+3D全视野、+3D上级视网膜和+3D下级视网膜近视离焦60 min。在散焦60分钟之前和之后，使用高分辨率、中央凹中心垂直OCT行扫描检查中央5 mm（17度）黄斑区的脉络膜厚度，同时使用安装在Spectralis OCT设备上的Badal视力计和冷镜系统施加光学散焦。结果在对照组中，平均5 mm黄斑区的脉络膜厚度减少了-4 +/-7 μ m（p = 0.01），这很可能是由于本研究的独特刺激条件。平均黄斑脉络膜厚度在全视野（+2 +/-8 μ m）、下视网膜（+3 +/-7 μ m）和上级视网膜近视散焦（+5 +/-9 μ m）期间增加，表示与对照期相比脉络膜显著增厚（所有p < 0.05）。离焦引起的黄斑脉络膜厚度变化在上级和低级半视网膜区之间存在差异（F-2.26，F- 54.27 = 29.75，p < 0.001）。当仅上级视网膜暴露于近视散焦时，上级区域的脉络膜增厚（+7 +/- 8 μ m，p < 0.001），但在下部区域没有显著变化（+3 +/- 9 μ m，p = 0.12）。当仅下方视网膜暴露于近视性散焦时，脉络膜向内侧增厚（+4 +/-8 μ m，p = 0.005），在上级区域未观察到显著变化（+1 +/-8 μ m，p = 0.46）。结论这些发现提供了证据支持局部区域脉络膜反应近视离焦在人眼，半视野近视离焦导致显着增厚的脉络膜局部视网膜区域暴露于离焦。人类脉络膜对半视野近视散焦的局部反应的新发现，特别是在上级半视网膜中，可能对优化近视控制干预的光学设计具有重要意义。
Purpose To examine the regional changes in human choroidal thickness following short-term exposure to hemifield myopic defocus using optical coherence tomography (OCT). Methods The central 26 visual field of the left eye of 25 healthy young adults (mean age 26 +/- 5 years) was exposed to 60 min of clear vision (control session), +3 D full-field, +3 D superior retinal and +3 D inferior retinal myopic defocus, with the right eye occluded. Choroidal thickness across the central 5 mm (17 degrees) macular region was examined before and after 60 min of defocus using a high-resolution, foveal centred vertical OCT line scan, with optical defocus simultaneously imposed using a Badal optometer and cold mirror system mounted on a Spectralis OCT device. Results Averaged across the central 5 mm macular area, choroidal thickness decreased by -4 +/- 7 mu m during the control session (p = 0.01), most likely due to the unique stimulus conditions of this study. The mean macular choroidal thickness increased during full-field (+2 +/- 8 mu m), inferior retinal (+3 +/- 7 mu m) and superior retinal myopic defocus (+5 +/- 9 mu m), representing a significant thickening of the choroid compared to the control session (all p < 0.05). The defocus induced changes in macular choroidal thickness differed between the superior and inferior hemiretinal regions (F-2.26,F- 54.27 = 29.75, p < 0.001). When only the superior retina was exposed to myopic defocus, the choroid thickened in the superior region (+7 +/- 8 mu m, p < 0.001), but did not change significantly in the inferior region (+3 +/- 9 mu m, p = 0.12). When only the inferior retina was exposed to myopic defocus, the choroid thickened inferiorly (+4 +/- 8 mu m, p = 0.005), with no significant change observed in the superior region (+1 +/- 8 mu m, p = 0.46). Conclusions These findings provide evidence supporting a local regional choroidal response to myopic defocus in the human eye, with hemifield myopic defocus leading to significant thickening of the choroid localised to the retinal region exposed to defocus. The novel finding of a localised response of the human choroid to hemifield myopic defocus, particularly in the superior hemiretina, may have important implications in optimising the optical design of myopia control interventions.