Mitochondrial genotype associated with longevity
Mitochondrial genotype associated with longevity
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DOI：
10.1016/s0140-6736(05)78211-8
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发表时间：
1998-01-17
期刊：
影响因子：
168.9
通讯作者：
Yagi, K
中科院分区：
文献类型：
--
作者：
Tanaka, M;Gong, JS;Yagi, K
据报道，线粒体 DNA (mtDNA) 突变导致线粒体脑肌病、心肌病和糖尿病。有人提出，体细胞中 mtDNA 突变的积累会导致衰老和退行性疾病。 1 线粒体DNA的序列多样性在个体之间很明显，因为线粒体DNA的进化速度比核DNA的进化速度高5-10倍。一项关于冠心病的流行病学研究表明，与父亲死亡年龄相比，寿命与母亲年龄的关系更为密切。 2 母系遗传的线粒体基因型可能会影响 mtDNA 的氧化损伤、mtDNA 突变的积累率以及退化的易感性
Mutations of mitochondrial DNA (mtDNA) have been reported in mitochondrial encephalomyopathies, cardiomyopathies, and diabetes mellitus. It has been proposed that accumulation of mtDNA mutations in somatic cells contributes to ageing and to degenerative diseases. 1 Sequence diversity of mtDNA is marked between individuals, because the evolutionary rate of mtDNA is 5–10 times higher than that of nuclear DNA. An epidemiological study on coronary heart disease has indicated that longevity is more strongly associated with age of maternal than age of paternal death. 2 It may be that maternally transmitted mitochondrial genotypes influence oxidative damage to mtDNA, the accumulation rate of mtDNA mutations, and susceptibility to degenerative