Three-dimensional T1 mapping for dGEMRIC at 3.0 T using the look locker method
Three-dimensional T1 mapping for dGEMRIC at 3.0 T using the look locker method
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DOI：
10.1097/01.rli.0000195842.49255.ea
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发表时间：
2006-02-01
影响因子：
6.7
通讯作者：
Prasad, P
中科院分区：
文献类型：
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作者：
Kimelman, T;Vu, A;Prasad, P
目的：本研究的目的是基于Look Locker方案实现3.0 T下dGEMRIC的三维（3-D） T1映射序列（3DLL）。材料和方法：由于目前所有关于dGEMRIC的报道都是在1.5 T，并且大多使用2-D IR快速自旋回波（FSE），因此使用3DLL和2-D IR-FSE序列在1.5 T和3.0 T获取数据。使用不同浓度Gd(DTPA)2的幻影，使用dGEMRIC技术对7名受试者（3名无症状，4名有症状）进行扫描。结果：用3DLL获得的假体T1测量值与用二维IR-FSE获得的T1测量值非常吻合。使用双尾配对t检验，在所有受试者中获得的两个部分的TI （Gd）测量值在两种场强下均无统计学差异（在1.5 t时P = 0.07，在3.0 t时P = 0.07）。结论：本文提供的初步数据表明，3DLL序列提供了准确的TI值，具有足够的面内分辨率，并且可以在不到10分钟的时间内完全覆盖关节。
Objective: The objective of this study was to implement a three-dimensional (3-D) T1 mapping sequence (3DLL) at 3.0 T for dGEMRIC based on the Look Locker scheme.Materials and Methods: Because all current reports on dGEMRIC are at 1.5 T and mostly using 2-D IR fast spin echo (FSE), data were acquired at 1.5 T and 3.0 T with both 3DLL and 2-D IR-FSE sequence. Phantoms with different concentrations of Gd(DTPA)2were used and seven subjects (three asymptornatic, four symptomatic) were scanned using the dGEMRIC technique.Results: The T1 measurements obtained on the phantom with 3DLL show very good agreement with those acquired with 2-D IR-FSE. Using a two-tailed paired t test, the TI (Gd) measurements in two sections obtained in all subjects with both sequences were found to be statistically indistinguishable at either field strength (P = 0.07 at 1.5 T and P = 0.07 at 3.0 T).Conclusions: The preliminary data presented here suggest that the 3DLL sequence provides accurate TI values with sufficient in-plane resolution and allows full joint coverage in less than 10 minutes.