Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men
Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men
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DOI：
10.1038/ijo.2010.76
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发表时间：
2010-09-01
影响因子：
4.9
通讯作者：
Wittert, G. A.
中科院分区：
文献类型：
--
作者：
Khoo, J.;Piantadosi, C.;Wittert, G. A.
目的：腹型肥胖和2型糖尿病与男性勃起和排尿功能障碍有关。减肥对性功能和下尿路症状（LUTS）的改善程度尚不清楚。受试者：我们比较了使用代餐进行8周低热量饮食的效果（Kicstart）对胰岛素敏感性、血浆睾酮水平、勃起功能（通过国际勃起功能指数IIEF-5的五项版本测量），性欲（通过性欲量表，SDI测量）和LUTS（通过国际前列腺症状评分，IPSS测量），在腹部肥胖（体重指数>= 30公斤/米（-2），腰围（WC）>= 102 cm）的男性（平均年龄49.7岁），饮食不复杂或口服降糖药治疗的2型糖尿病患者（n = 19）或无2型糖尿病患者（n = 25），与对照组的非糖尿病男性（n = 26）具有相似的体重指数和WC.Results：体重减轻10%左右，是显着相关的增加胰岛素敏感性，血浆睾酮水平，IIEF-5和SDI评分，以及减少WC和IPSS评分，在糖尿病以及非糖尿病男性。体重减轻程度与血浆睾酮水平（r = -0.34）、勃起功能（r = -0.26）和LUTS（r = 0.65）的改善显著相关。LUTS的减少与血浆睾酮（r = -0.35）、勃起功能（r = -0.42）和性欲（r =-0.40.Conclusions：饮食诱导的体重减轻显著且快速地改善了伴或不伴糖尿病的肥胖中年男性的性功能，并减少了LUTS。International Journal of Obesity（2010）34，1396-1403; doi：10.1038/ijo.2010.76; 2010年4月20日在线发表
Objective: Abdominal obesity and type 2 diabetes mellitus are associated with erectile and urinary dysfunction in men. The extent to which sexual function and lower urinary tract symptoms (LUTSs) are improved by weight loss remains unclear.Subjects: We compared the effects of 8 weeks of a low-calorie diet using meal replacements (Kicstart) on insulin sensitivity, plasma testosterone levels, erectile function (measured by the five-item version of the International Index of Erectile Function, IIEF-5), sexual desire (measured by the Sexual Desire Inventory, SDI) and LUTS (measured by the International Prostate Symptom Score, IPSS), in abdominally obese (body mass index >= 30 kg m(-2), waist circumference (WC) >= 102 cm) men (mean age 49.7 years) with uncomplicated diet or oral hypoglycemic-treated type 2 diabetes mellitus (n = 19) or without type 2 diabetes mellitus (n = 25), with a control group of nondiabetic men (n = 26) with similar body mass index and WC.Results: Weight loss of similar to 10% was significantly associated with increased insulin sensitivity, plasma testosterone levels, IIEF-5 and SDI scores, as well as reduced WC and IPSS scores, in diabetic as well as nondiabetic men. The degree of weight loss was significantly associated with improvements in plasma testosterone levels (r = -0.34), erectile function (r = -0.26) and LUTS (r = 0.65). Reduction in LUTS was significantly associated with increased plasma testosterone (r = -0.35), erectile function (r = -0.42) and sexual desire (r = -0.40).Conclusions: Diet-induced weight loss significantly and rapidly improves sexual function, and reduces LUTS, in obese middle-aged men with or without diabetes. International Journal of Obesity (2010) 34, 1396-1403; doi: 10.1038/ijo.2010.76; published online 20 April 2010