Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease
Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease
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DOI：
10.1016/j.jjcc.2014.02.003
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发表时间：
2014-09-01
影响因子：
2.5
通讯作者：
Takeishi, Yasuchika
中科院分区：
文献类型：
--
作者：
Yoshihisa, Akiomi;Takiguchi, Mai;Takeishi, Yasuchika
背景资料：慢性阻塞性肺疾病（COPD）常与心力衰竭（HF）并存，被认为与HF患者的不良结局相关。然而，心血管功能的特点和详细的全因死亡率的HF与COPD.Methods和结果：Concretive 378例患者入院HF进行肺功能测定被分为三组：HF无COPD（非COPD组，n = 272），HF轻度COPD（GOLD I组，n = 82），HF中度COPD（GOLD II组，n = 24）。与非COPD组相比，GOLD II组具有（1）较高的肌钙蛋白T（p = 0.009）;（2）较高的心踝血管指数（p = 0.032）;（3）左右心室的心脏收缩和舒张功能相似。此外，GOLD II组的心源性（p = 0.049）、非心源性（p = 0.001）和全因死亡率（p = 0.002）高于非COPD组和GOLD I组。重要的是，在考克斯比例风险分析，黄金阶段II是一个独立的预测心脏（p = 0.038），非心脏（p = 0.036），和所有原因的死亡率（p = 0.015）在HF patient.Conclusions：HF合并中度COPD患者（黄金阶段II）有更大的心肌损伤，更大的动脉僵硬度，更高的心脏和非心脏死亡率。(C)2014年日本心脏病学院。由爱思唯尔有限公司出版。保留所有权利。
Background: Chronic obstructive pulmonary disease (COPD) often coexists with heart failure (HF), and is considered to be associated with adverse outcomes in HF patients. However, the features of cardiovascular function and the detailed all-cause mortality of HF with COPD remain unclear.Methods and results: Consecutive 378 patients admitted for HF who underwent spirometry were divided into three groups: HF without COPD (non-COPD group, n = 272), HF with mild COPD (GOLD I group, n = 82), and HF with moderate COPD (GOLD II group, n = 24). The GOLD II group, as compared to non-COPD group, had (1) higher troponin T (p = 0.009): (2) greater cardio-ankle vascular index (p = 0.032); and (3) similar cardiac systolic and diastolic function of the right and left ventricle. In addition, rates of cardiac (p = 0.049), non-cardiac (p = 0.001), and all-cause mortality (p = 0.002) were higher in GOLD II group than in non-COPD and GOLD I groups. Importantly, in the Cox proportional hazard analyses, the GOLD stage II was an independent predictor of cardiac (p = 0.038), non-cardiac (p = 0.036), and all-cause mortality (p = 0.015) in HF patients.Conclusions: HF patients with coexistent moderate COPD (GOLD stage II) have greater myocardial damage, greater arterial stiffness, and higher cardiac and non-cardiac mortality. (C) 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.