Immobilizing natural macromolecule on PLGA electrospun nanofiber with surface entrapment and entrapment-graft techniques
Immobilizing natural macromolecule on PLGA electrospun nanofiber with surface entrapment and entrapment-graft techniques
复制标题
采用表面包埋和包埋接枝技术将天然大分子固定在 PLGA 电纺纳米纤维上
DOI：
10.1016/j.colsurfb.2012.01.017
复制
发表时间：
2012-06-01
影响因子：
5.8
通讯作者：
Zheng, Y. F.
中科院分区：
文献类型：
--
作者：
Meng, Z. X.;Zeng, Q. T.;Zheng, Y. F.
表面包埋法是将天然大分子包埋在合成高分子表面的一种简便方法。本研究采用表面包埋法和包埋-接枝法制备了明胶改性和海藻酸钠/明胶改性的PLGA纳米纤维膜。每个单一的改性PLGA纤维的表面形态与未处理的PLGA纳米纤维的表面形态一样光滑。水接触角测量和拉伸测试结果表明，表面包埋不仅改善了亲水性，而且提高了改性纳米纤维膜的机械性能。此外，海藻酸钠/明胶复合改性的PLGA纳米纤维膜比单纯明胶改性的PLGA纳米纤维膜具有更高的亲水性和更好的生物相容性，表明表面包埋法是一种简单有效的静电纺丝纳米纤维膜表面改性方法。(C)2012爱思唯尔有限公司版权所有。
Surface entrapment is a convenient method to immobilize the natural macromolecules on the surface of synthetic polymers. In this study, the gelatin modified and sodium alginate/gelatin modified PLGA nanofibrous membranes were fabricated via surface entrapment and entrapment-graft techniques. The surface morphology of the each single modified PLGA nanofiber was as smooth as that of untreated PLGA nanofibers. The results of water angle contact measurements and tensile tests showed that the surface entrapment cannot only improve the hydrophilicity but also enhance mechanical properties of the modified nanofibrous membranes. In addition, the sodium alginate/gelatin modified electrospun PLGA nanofibrous membrane exhibited higher hydrophilicity and better biocompatibility than the simply gelatin modified PLGA nanofibrous membrane, which suggested the surface entrapment is a facile and efficient approach to surface modification for electrospun nanofibours membranes. (C) 2012 Elsevier B.V. All rights reserved.