Loss of E-cadherin expression correlates with poor differentiation and invasion into a acent organs in gastric adenocarcinomas
Loss of E-cadherin expression correlates with poor differentiation and invasion into a acent organs in gastric adenocarcinomas
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DOI：
10.1016/j.canlet.2003.07.007
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发表时间：
2003-11-10
期刊：
影响因子：
9.7
通讯作者：
Hsiao, M
中科院分区：
文献类型：
--
作者：
Chen, HC;Chu, RY;Hsiao, M
E-钙粘蛋白表达的扰动导致细胞粘附的丧失，可能导致细胞转化和肿瘤进展。本研究的目的是检测E-cadherin在不同分类系统的各亚型胃癌中的表达，并探讨E-cadherin在细胞分化、肿瘤侵袭和转移中的作用。应用免疫组化方法检测84例胃腺癌组织中E-cadherin的表达，并与临床病理参数进行相关性分析。我们的结果显示，在乳头状腺癌、管状腺癌、低分化腺癌、印戒细胞腺癌和黏液腺癌中，E-cadherin表达缺失率分别为0%（0/3）、20.0%（9/45）、48%（15/31）、100%（3/3）和100%（2/2）。E-cadherin表达的减少与分化程度呈负相关。根据Lauren和Ming的组织学分类，弥漫型和浸润型胃癌中E-cadherin表达缺失率分别为65%和64%，显著高于肠型和扩张型胃癌中E-cadherin表达缺失率分别为20%和22%（P <0.001）。E-cadherin表达缺失与肿瘤浸润密切相关（P < 0.05）。此外，E-cadherin表达缺失与生存率差之间存在临界相关性（P = 0.109）。这些数据表明E-cadherin表达与胃癌分化程度有显著相关性。E-cadherin表达的缺失可能与胃癌向邻近器官的浸润有关。(C)2003年由Elsevier爱尔兰有限公司出版
Perturbation in E-cadherin expression leads to loss of cellular adhesion with possible consequence of cellular transformation and tumor progression. The aims of this study were to determine E-cadherin expression in each subtype of gastric cancer classified by different classification systems, and to investigate the role of E-cadherin in cell differentiation, cancer invasion and metastasis. Expression of E-cadherin was analyzed in 84 patients with gastric adenocarcinoma by immunohistochemistry and correlated with clinicopahotlogical parameters. Our results showed loss of E-cadherin expression in 0% (0/3), 20.0% (9/45), 48% (15/31), 100% (3/3) and 100% (2/2) of papillary, tubular, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma by Japanese histological classification. The reduction of E-cadherin expression was inversely correlated with the grade of differentiation. According to the histological classification of Lauren and Ming, the frequency of lost E-cadherin expression was higher in diffuse type (65%) and infiltrative type (64%) gastric cancer than in intestinal type (20%, P < 0.001) and expanding type cancer (22%, P < 0.001), respectively. The loss of E-cadherin expression was significantly associated with tumor invasion (P < 0.05). Furthermore, there was a borderline association between the loss of E-cadherin expression and poor survival (P = 0.109). These data demonstrated a striking correlation between E-cadherin expression and the differentiation of gastric carcinoma. The loss of E-cadherin expression may contribute to gastric cancer invasion to adjacent organs. (C) 2003 Published by Elsevier Ireland Ltd.