Cortisol blockade of progesterone: A possible molecular mechanism involved in the initiation of human labor
Cortisol blockade of progesterone: A possible molecular mechanism involved in the initiation of human labor
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DOI：
10.1038/nm0596-556
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发表时间：
1996-05-01
期刊：
影响因子：
82.9
通讯作者：
Majzoub, JA
中科院分区：
文献类型：
--
作者：
Karalis, K;Goodwin, G;Majzoub, JA
在大多数哺乳动物中，分娩是由孕酮撤退预示的，这被认为与导致分娩的多种途径的激活有关。在人类中，尽管胎盘孕酮的产生没有减少，但分娩前类似途径的激活表明存在内源性抗孕酮，我们推断可能是皮质醇，其从胎儿肾上腺的分泌在人类妊娠结束时显著增加。我们报告说，在原代培养的人胎盘，皮质醇能够竞争的行动，孕激素的促肾上腺皮质激素释放激素（CRH）基因的调节。CRH是妊娠末期胎盘组织中高表达的一种肽类物质，被认为参与了分娩时机的调节。这些发现提供了一个在人类妊娠结束时功能性孕酮撤退的模型，这可能与分娩的开始有关。
In most mammals, labor is heralded by progesterone withdrawal, which is believed to be related to the activation of multiple pathways leading to parturition. In humans, despite no decrease in placental progesterone production, activation of similar pathways preceding labor suggests the presence of an endogenous antiprogestin, which we reasoned might: be cortisol, whose secretion from the fetal adrenal rises markedly at the end of human gestation. We report that in primary cultures of human placenta, cortisol is able to compete with the action of progesterone in the regulation of the corticotropin-releasing hormone (CRH) gene. CRH is a peptide highly expressed in human placenta at the end of gestation, which has been suggested to be involved in regulating the timing of parturition. These findings provide a model for functional progesterone withdrawal at the end of human pregnancy, which may be involved in the initiation of labor.