COLONOSCOPIC SURVEILLANCE REDUCES MORTALITY FROM COLORECTAL-CANCER IN ULCERATIVE-COLITIS
COLONOSCOPIC SURVEILLANCE REDUCES MORTALITY FROM COLORECTAL-CANCER IN ULCERATIVE-COLITIS
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DOI：
10.1016/0016-5085(93)90715-o
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发表时间：
1993-08-01
期刊：
影响因子：
29.4
通讯作者：
HAGGITT, RC
中科院分区：
文献类型：
--
作者：
CHOI, PM;NUGENT, FW;HAGGITT, RC
背景：为了控制长期溃疡性结肠炎患者结直肠癌风险的增加，广泛推荐进行结肠镜检查。方法：评估结肠镜监测在影响结直肠癌相关死亡率中的作用，进行结果分析。结果：41例溃疡性结肠炎伴癌患者中，19例接受结肠镜监测，22例未接受结肠镜监测。监测组Dukes分期癌明显早于对照组（P= 0.039）。监测组有4名患者死亡，而非监测组有11名患者死亡。监测组5年生存率为77.2%，未监测组为36.3% （P= 0.026）。结论：这些结果表明，结肠镜监测通过允许在早期Dukes期检测癌症来降低结直肠癌相关死亡率。
Background:To control the increased risk of colorectal carcinoma in patients with long-standing ulcerative colitis, surveillance colonoscopy is widely recommended.Methods:To assess the role of colonoscopic surveillance in affecting colorectal carcinoma-related mortality, an outcome analysis was performed.Results:Among the total of 41 patients who developed carcinoma associated with ulcerative colitis, 19 patients were under colonoscopic surveillance and 22 patients were not. Carcinoma was detected at a significantly earlier Dukes' stage in the surveillance group (P= 0.039). Four patients in the surveillance group died, compared with 11 patients in the no-surveillance group. The 5-year survival rate was 77.2% for the surveillance group and 36.3% for the no-surveillance group (P= 0.026).Conclusions:These results suggest that colonoscopic surveillance reduces colorectal carcinoma-related mortality by allowing the detection of carcinoma at an earlier Dukes' stage.