Re-sequencing of a virulent strain of Campylobacter jejuni NCTC11168 reveals potential virulence factors
Re-sequencing of a virulent strain of Campylobacter jejuni NCTC11168 reveals potential virulence factors
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DOI：
10.1016/j.resmic.2012.10.002
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发表时间：
2013-01-01
影响因子：
2.6
通讯作者：
Joens, Lynn A.
中科院分区：
文献类型：
--
作者：
Cooper, Kerry K.;Cooper, Margarethe A.;Joens, Lynn A.
空肠弯曲菌菌株的体外传代导致表型变化和毒力的普遍丧失，基因组测序的菌株C也是如此。jejuni NCTC 11168.对NCTC 11168强毒株的重测序鉴定出41个SNP或indel，涉及20个基因、4个基因间区域和3个假基因。这些基因包括6个运动基因、2个趋化基因、3个假设基因和1个荚膜生物合成基因，它们可能在C.空肠毒力此外，我们发现插入在Cj0676和Cj1470c，在无毒NCTC 11168的假基因，但在有毒NCTC 11168的功能蛋白。(C)2012巴斯德研究所。由Elsevier Masson SAS出版。All rights reserved.
In vitro passage of Campylobacter jejuni strains results in phenotypic changes and a general loss of virulence, as is the case with the genome-sequenced strain C. jejuni NCTC11168. Re-sequencing of a virulent strain of NCTC11168 identified 41 SNPs or indels involving 20 genes, four intergenic regions and three pseudogenes. The genes include six motility genes, two chemotaxis genes, three hypothetical genes and a capsule biosynthesis gene, which might have a critical role in C. jejuni virulence. Additionally, we found an insertion in both Cj0676 and Cj1470c, pseudogenes in avirulent NCTC11168, but functional proteins in virulent NCTC11168. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.