Outbreak of OXA-48-Positive Carbapenem-Resistant Klebsiella pneumoniae Isolates in France
Outbreak of OXA-48-Positive Carbapenem-Resistant Klebsiella pneumoniae Isolates in France
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DOI：
10.1128/aac.01452-10
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发表时间：
2011-05-01
影响因子：
4.9
通讯作者：
Nordmann, Patrice
中科院分区：
文献类型：
--
作者：
Cuzon, Gaelle;Ouanich, Jocelyne;Nordmann, Patrice
对2010年4月至6月从法国巴黎郊区维伦纽夫-圣乔治医院重症监护室的10名患者中分离到的17株产生OXA-48碳青霉烯酶的肺炎克雷伯菌进行了分析。有7名患者受到感染，其中5名患者至少接受了碳青霉烯类药物治疗，5名患者死亡。分子分析表明，分离株属于单一克隆，含有携带blA(OXA-48)基因的70kb质粒，并共同产生CTX-M-15和TEM1β-内酰胺酶。这是法国首次报告的产OXA-48肺炎克雷伯菌的暴发。
Seventeen Klebsiella pneumoniae isolates producing the OXA-48 carbapenemase, obtained from 10 patients hospitalized from April to June 2010, mostly in the medical intensive care unit of the Villeneuve-Saint-Georges Hospital in a suburb of Paris, France, were analyzed. Seven patients were infected, of whom five were treated at least with a carbapenem, and five patients died. Molecular analysis showed that the isolates belonged to a single clone that harbored a 70-kb plasmid carrying the bla(OXA-48) gene and coproduced CTX-M-15 and TEM-1 beta-lactamases. This is the first reported outbreak of OXA-48-producing K. pneumoniae isolates in France.