Id proteins at the cross-road of development and cancer
Id proteins at the cross-road of development and cancer
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DOI：
10.1038/sj.onc.1205093
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发表时间：
2001-12-20
期刊：
影响因子：
8
通讯作者：
Iavarone, A
中科院分区：
文献类型：
--
作者：
Lasorella, A;Uo, T;Iavarone, A
已经积累了大量的证据，证明了Id蛋白在细胞生长的不同方面的主导作用。一般来说，本构性表达的Id不仅可以阻断细胞分化，还可以促进细胞增殖。在某些情况下，它足以使细胞不朽或诱导致癌转化。最近的一项发现极大地支持了Id蛋白在晚期人类恶性肿瘤中的作用，在这些恶性肿瘤中，它们经常被解除管制，而Id蛋白对许多基本的改变起着关键的作用，这些改变共同决定了恶性肿瘤的生长。与生长信号自给自足和对生长抑制信号不敏感相关的持续增殖、持续的新血管生成、组织侵袭性和肿瘤细胞的迁移能力都依赖于Id蛋白的无限可用性。值得注意的是，许多这些特征都是由Id蛋白在生理上推动的，以支持正常发育。我们认为，Id参与癌症的多个基本特征可能是前所未有的治疗机会的基础。
A large body of evidence has been, accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell differentiation but also drives proliferation. In some settings, it is sufficient to render cells immortal or induce oncogenic transformation. The participation of Id proteins in advanced human malignancy, where they are frequently deregulated, has been dramatically bolstered by the recent discovery that Id exert pivotal contributions to many of the essential alterations that collectively dictate malignant growth. Relentless proliferation associated with self-sufficiency in growth signals and insensitivity to growth inhibitory signals, sustained neoangiogenesis, tissue invasiveness and migration capabilities of tumor cells all share dependency on the unlimited availability of Id proteins. It is remarkable that many of these features recapitulate those physiologically propelled by Id proteins to support normal development. We propose that the participation of Id in multiple fundamental traits of cancer may be the basis for unprecedented therapeutic opportunities.