Do biofilms confer a pro-carcinogenic state?
Do biofilms confer a pro-carcinogenic state?
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DOI：
10.1080/19490976.2015.1121363
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发表时间：
2016-01-01
期刊：
影响因子：
12.2
通讯作者：
Sears, Cynthia L.
中科院分区：
文献类型：
--
作者：
Dejea, Christine M.;Sears, Cynthia L.
现在人们普遍认为，包括肥胖、癌症和炎症性肠道疾病在内的一系列人类疾病与微生物区系密切相关。几十年来，微生物区系一直被认为与结肠癌的发病机制有关。我们最近的工作表明，粘膜微生物区系组织成生物膜标志着人类结肠癌的一个子集。此外，结肠癌宿主体内生物膜阳性的结肠粘膜产生一种罕见的多胺代谢产物N(1)，N(12)-二乙酰精胺，值得进一步研究以确定其作为结肠肿瘤标志物的作用。
It is now widely recognized that a range of human diseases, including obesity, cancer and inflammatory bowel disease, is strongly linked to the microbiota. For decades, the microbiota has been proposed to contribute to the pathogenesis of colon cancer. Our recent work reveals that the organization of the mucosal microbiota into biofilms marks a subset of human colon cancer. Further, biofilm-positive colon mucosa in the colon cancer host yields an infrequently detected polyamine metabolite, N(1), N(12)-diacetylspermine, that deserves further study to determine its utility as a marker for colon neoplasia.