Synthesis of Acyl Hydrazides via a Radical Chemistry of Azocarboxylic tert-Butyl Esters.
Synthesis of Acyl Hydrazides via a Radical Chemistry of Azocarboxylic tert-Butyl Esters.
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DOI：
10.1021/acs.joc.2c00139
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发表时间：
2022-05
期刊：
影响因子：
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通讯作者：
Hong-Xia Zhang;Rui-Li Guo;Xing-Long Zhang;Meng-Yue Wang;Bao-Yin Zhao;Ya-Ru Gao;Qiong Jia;Yong-Qiang Wang
中科院分区：
文献类型：
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作者：
Hong-Xia Zhang;Rui-Li Guo;Xing-Long Zhang;Meng-Yue Wang;Bao-Yin Zhao;Ya-Ru Gao;Qiong Jia;Yong-Qiang Wang
A new chemistry of azo compounds, that is, addition of free radicals generated in situ to access various acyl hydrazides, has been developed. The protocol provides a novel strategy for the synthesis of valuable acyl hydrazides. The transformation features mild reaction conditions, good tolerance of functional groups, and a broad substrate scope. In view of the importance of acyl hydrazides in functional materials and medicinal chemistry, this approach would find broad applications.
