Neuroprotective potential of exercise preconditioning in stroke.
Neuroprotective potential of exercise preconditioning in stroke.
复制标题
DOI：
--
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
M. R. Islam;Michael F. Young;C. Wrann
中科院分区：
文献类型：
--
作者：
M. R. Islam;Michael F. Young;C. Wrann
中风是世界上死亡率和发病率的主要原因之一，治疗干预的可用性有限。在不同的临床前和临床设置中，运动已被证明可以改善脑卒中的功能结果。在临床前卒中模型中，运动预处理诱导的神经保护被认为是通过其恢复脑血管和血脑屏障完整性、促进神经发生、帮助对抗神经炎症和兴奋性毒性的能力来介导的。在这篇简短的综述中，我们将总结在临床前卒中研究中描述的运动预处理的分子机制。我们还将讨论缺血前运动的神经保护作用。
Stroke is one of leading causes of mortality and morbidity in the world with limited availability of therapeutic intervention. Exercise has been shown to improve stroke functional outcome in different preclinical and clinical setup. Exercise preconditioning induced neuroprotection in preclinical stroke models is believed to be mediated through its ability to restore brain vasculature and blood brain barrier integrity, promote neurogenesis, and help fight against neuroinflammation and excitotoxicity. In this short review, we will summarize the molecular mechanisms of exercise preconditioning described in preclinical stroke studies. We will also discuss the neuroprotective effects of pre-ischemic exercise.