Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan.
Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan.
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关于出生结果和脂肪因子表达的母体和脐带血液中双酚A浓度的生物监测：台湾的一项出生队列研究。
DOI：
10.1186/1476-069x-10-94
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发表时间：
2011-11-03
期刊：
影响因子：
--
通讯作者：
Chuang CY
中科院分区：
文献类型：
--
作者：
Chou WC;Chen JL;Lin CF;Chen YC;Shih FC;Chuang CY
双酚A（BPA）是一种塑料材料的密封剂和助焊剂，已被确定为一种内分泌干扰化学品。产前暴露于BPA会对胎儿的生长和发育产生严重的不利影响。本研究旨在评估孕妇和脐带血中的BPA浓度，并调查母体BPA暴露是否影响胎儿结局，包括低出生体重（LBW），小于胎龄（SGA），高瘦素（HLP）和低脂联素（LAD）分泌。我们用高效液相色谱/紫外检测器测量了母亲血液（n = 97）和脐带血（n = 97）的BPA水平。采用酶联免疫吸附法分别测定瘦素和脂联素的蛋白分泌量。进行逻辑回归以估计母亲暴露于BPA对新生儿LBW、SGA和脂肪因子不良作用的影响。母体血和胎儿脐带血中BPA浓度的几何平均值分别为2.5 ng/ml和0.5 ng/ml。LBW风险增加（OR 2.42，95%置信区间（CI）1.72-3.36），SGA（OR 2.01，95%CI 1.39-3.01），以及瘦素的不良作用在母体BPA暴露量最高四分位数的男性新生儿中观察到脂联素（OR 1.67，95% CI 1.12-2.25）和脂联素（OR 1.25，95% CI 1.52-3.97）。产前BPA暴露水平升高可增加新生儿（尤其是男婴）LBW、SGA和脂肪因子不良作用的风险。这些结果提供了进一步的证据，表明母亲接触与不良出生结果相关。
Bisphenol A (BPA) is a sealant and flux of plastic materials and has been determined to be an endocrine-disrupting chemical. Prenatal exposure to BPA can lead to substantial adverse effects on fetal growth and development. This study was conducted to assess BPA concentration in pregnant women and umbilical cord blood, and to investigate whether maternal BPA exposure affected fetal outcomes including lower birth weight (LBW), smaller size for gestational age (SGA), and high leptin (HLP) and low adiponectin (LAD) secretion. We measured the BPA levels of maternal blood (n = 97) and umbilical cord blood (n = 97) with a high-performance liquid chromatography/UV detector. The protein secretion of leptin and adiponectin were separately determined using enzyme-linked immunosorbent assay. A logistic regression was performed to estimate the effects of maternal exposure to BPA on LBW, SGA, and adverse action of adipokines in newborns. The geometric means of BPA concentration in maternal blood and fetal cord blood were 2.5 ng/ml and 0.5 ng/ml, respectively. Elevated risks of LBW (OR 2.42, 95% confidence interval (CI) 1.72-3.36), SGA (OR 2.01, 95% CI 1.39-3.01), and adverse action of leptin (OR 1.67, 95% CI 1.12-2.25) and adiponectin (OR 1.25, 95% CI 1.52-3.97) were observed in male neonates in the highest quartile of maternal BPA exposure. Elevated prenatal BPA exposure increased the risk of LBW, SGA, and adverse actions of adipokines in neonates, especially in male infants. These results provide further evidence that maternal exposure is correlated with adverse birth outcomes.