Neuroprotective effects of aspirin in patients with acute cerebral infarction
Neuroprotective effects of aspirin in patients with acute cerebral infarction
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DOI：
10.1016/s0304-3940(03)00029-6
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发表时间：
2003-03-27
影响因子：
2.5
通讯作者：
Dávalos, A
中科院分区：
文献类型：
--
作者：
Castillo, J;Leira, R;Dávalos, A
阿司匹林可以减轻缺血性脑损伤。本研究的目的是探讨阿司匹林对急性中风后谷氨酸释放的影响。我们研究了 238 名首次发作半球缺血性卒中且持续时间小于 24 It 的患者。当加拿大中风量表在入院至 48 小时之间下降 I 分或以上时，即可诊断出早期神经功能恶化。根据入院时获得的脑脊液 (CSF) 样本测定谷氨酸。 63 名患者在中风发作时每天接受 75-500 毫克阿司匹林治疗。未服用阿司匹林的患者组中脑脊液谷氨酸浓度较高（8.9 +/- 5.2 vs. 4.9 +/- 3.1 muM/l，P < 0.0001）。中风发作时服用阿司匹林治疗可以将早期神经功能恶化的风险降低 97%，并且在进一步调整谷氨酸浓度后，这种效果保持不变。这些发现表明，低剂量的阿司匹林可能有助于治疗脑缺血患者，不仅因为其抗血栓形成特性，而且还因为其直接的神经保护作用。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
Aspirin may reduce ischemic brain injury. The aim of this study was to explore the effect of aspirin on glutamate release after acute stroke. We studied 238 patients with a first episode of hemispheric ischemic stroke of less than 24 It duration. Early neurological deterioration was diagnosed when the Canadian Stroke Scale dropped I or more points between admission and 48 h. Glutamate was determined on cerebrospinal fluid (CSF) samples obtained at admission. Sixty-three patients were undergoing treatment with 75-500 mg/day of aspirin at the time of stroke onset. CSF glutamate concentrations were higher in the group of patients not taking aspirin (8.9 +/- 5.2 vs. 4.9 +/- 3.1 muM/l, P < 0.0001). Aspirin treatment at stroke onset had a 97% risk reduction of early neurological deterioration, and this effect remained unchanged after a further adjustment for glutamate concentrations. These findings suggest that low doses of aspirin may be useful in the management of patients with cerebral ischemia, not only for its antithrombotic properties, but also by direct neuroprotective effects. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.