SENSITIVITY OF MAGNETIC-RESONANCE DIFFUSION-WEIGHTED IMAGING AND REGIONAL RELATIONSHIP BETWEEN THE APPARENT DIFFUSION-COEFFICIENT AND CEREBRAL BLOOD-FLOW IN RAT FOCAL CEREBRAL-ISCHEMIA
SENSITIVITY OF MAGNETIC-RESONANCE DIFFUSION-WEIGHTED IMAGING AND REGIONAL RELATIONSHIP BETWEEN THE APPARENT DIFFUSION-COEFFICIENT AND CEREBRAL BLOOD-FLOW IN RAT FOCAL CEREBRAL-ISCHEMIA
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DOI：
10.1161/01.str.26.4.667
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发表时间：
1995-04-01
期刊：
影响因子：
8.3
通讯作者：
JONES, SC
中科院分区：
文献类型：
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作者：
PEREZTREPICHIO, AD;XUE, M;JONES, SC
背景与目的磁共振（MR）弥散加权成像（DWI）是一种无创技术，在检测和准确定位脑卒中后一段时间内发生的梗死程度方面可能发挥重要作用。我们评估了DWI检测缺血的敏感性和特异性，并比较了DWI定量测量的表观扩散系数（ADC）和放射自显像脑血流量（CBF）在大鼠局灶性脑缺血实验模型中的表现。方法采用美国通用电气公司4.7 t水平孔磁CSIⅱ自屏蔽梯度系统进行磁共振成像。在缺血开始后41+/-6分钟（平均+/-SD）内获得DWI，并在169+/-14分钟重复，然后在237+/-21分钟测定CBF。然后比较每只动物的DWI、ADC和CBF图像。结果DWI在1小时和3小时检测异常的敏感性有显著差异，3小时DWI的敏感性与CBF的99%的敏感性没有差异。平均+/-SD ADC阈值为460+/-95 μ m(2)/s，与对侧ADC相比，缺血核心的低ADC高出45%。阈下ADC面积与缺血面积显著相关(r(2)= 0.69， P
Background and Purpose Magnetic resonance (MR) diffusion-weighted imaging (DWI), a noninvasive procedure, may play an important role in detecting and accurately localizing the extent of evolving infarction within the period immediately following stroke. We evaluated the sensitivity and specificity of DWI in detecting ischemia and compared a quantitative measure derived from the DWI, the apparent diffusion coefficient (ADC), with autoradiographic cerebral blood flow (CBF) in an experimental model of focal cerebral ischemia in rats.Methods MR imaging data were obtained with a General Electric 4.7-T horizontal bore magnet CSI II system with self-shielded gradients. DWI was acquired within 41+/-6 minutes (mean+/-SD) after onset of ischemia and repeated at 169+/-14 minutes, followed by CBF determination at 237+/-21 minutes. DWI, ADC, and CBF images from each animal were then compared.Results The sensitivities for detecting an abnormality at 1 and 3 hours for DWI were significantly different, and the sensitivity of 3-hour DWI did not differ from the CBF sensitivity of 99%. A mean+/-SD ADC threshold of 460+/-95 mu m(2)/s was defined as 45% higher than the low ADC in the ischemic core compared with the contralateral ADC. Subthreshold ADC area and ischemic area were significantly correlated (r(2)=.69, P