Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
复制标题
DOI：
10.1371/journal.pone.0018950
复制
发表时间：
2011-04-15
期刊：
影响因子：
3.7
通讯作者：
Kuroda M
中科院分区：
文献类型：
--
作者：
Funato H;Oda S;Yokofujita J;Igarashi H;Kuroda M
现在人们越来越关注动物和人类行为的表观遗传调控，包括应激反应和药物成瘾。表观遗传因素也会影响进食行为和代谢表型，例如肥胖和胰岛素敏感性。为了应对禁食和高脂肪饮食，内侧下丘脑改变调节摄食、新陈代谢和生殖行为的神经肽的表达。组蛋白脱乙酰酶 (HDAC) 参与基因表达的表观遗传控制，并根据各种环境因素改变行为。在这里，我们检查了小鼠下丘脑内侧中 HDAC 家族成员对禁食或高脂肪饮食的反应的表达。禁食后，HDAC3 和 -4 表达水平增加，而 HDAC10 和 -11 水平下降。四周的高脂肪饮食导致 HDAC5 和 -8 的表达增加。此外，禁食还减少了下丘脑腹内侧分区中乙酰化组蛋白 H3 和乙酰化组蛋白 H4 阳性细胞的数量。因此，HDAC 可能与不同代谢状态下内侧下丘脑基因表达谱的改变有关。
Increasing attention is now being given to the epigenetic regulation of animal and human behaviors including the stress response and drug addiction. Epigenetic factors also influence feeding behavior and metabolic phenotypes, such as obesity and insulin sensitivity. In response to fasting and high-fat diets, the medial hypothalamus changes the expression of neuropeptides regulating feeding, metabolism, and reproductive behaviors. Histone deacetylases (HDACs) are involved in the epigenetic control of gene expression and alter behavior in response to a variety of environmental factors. Here, we examined the expression of HDAC family members in the medial hypothalamus of mice in response to either fasting or a high-fat diet. In response to fasting, HDAC3 and −4 expression levels increased while HDAC10 and −11 levels decreased. Four weeks on a high-fat diet resulted in the increased expression of HDAC5 and −8. Moreover, fasting decreased the number of acetylated histone H3- and acetylated histone H4-positive cells in the ventrolateral subdivision of the ventromedial hypothalamus. Therefore, HDACs may be implicated in altered gene expression profiles in the medial hypothalamus under different metabolic states.
登录
查看更多内容
影响因子：
64.8
作者：
Alenghat, Theresa;Meyers, Katherine;Mullican, Shannon E.;Leitner, Kirstin;Adeniji-Adele, Adetoun;Avila, Jacqueline;Bucan, Maja;Ahima, Rexford S.;Kaestner, Klaus H.;Lazar, Mitchell A.
通讯作者：
Lazar, Mitchell A.
影响因子：
16.2
作者：
Dhillon, H;Zigman, JM;Lowelll, BB
通讯作者：
Lowelll, BB
影响因子：
64.8
作者：
Ng, Sheau-Fang;Lin, Ruby C. Y.;Morris, Margaret J.
通讯作者：
Morris, Margaret J.
影响因子：
3.3
作者：
Foo, K. S.;Brismar, H.;Broberger, C.
通讯作者：
Broberger, C.
影响因子：
4.8
作者：
Fischer, DD;Cai, R;Cohen, D
通讯作者：
Cohen, D