Molecular Basis of Tobacco Smoke-Induced Premature Skin Aging
Molecular Basis of Tobacco Smoke-Induced Premature Skin Aging
复制标题
DOI：
10.1038/jidsymp.2009.13
复制
发表时间：
2009-08-01
影响因子：
--
通讯作者：
Yamaguchi, Yuji
中科院分区：
文献类型：
--
作者：
Morita, Akimichi;Torii, Kan;Yamaguchi, Yuji
尽管现在人们普遍认识到烟草烟雾对皮肤有负面影响，但其皮肤老化影响背后的分子机制仍不确定。流行病学研究表明，吸烟是面部皱纹形成和皮肤过早衰老其他方面的强有力的独立预测因素。最近对人类和小鼠的体内研究提供了第一个直接证据，证明烟草烟雾会导致皮肤过早老化，并且他们已经开始揭示皮肤对此作出反应而发生的分子变化。水溶性烟草烟雾提取物在局部应用于培养的皮肤成纤维细胞时主要产生氧化应激，会损害胶原蛋白的生物合成。基质金属蛋白酶可降解胶原蛋白，由烟草烟雾提取物以及触发芳基烃受体 (AhR) 的其他成分以剂量依赖性方式诱导，AhR 是一种配体依赖性转录因子，介导多种环境污染物的毒性，包括 UVB 辐射在体内产生的光产物。烟草烟雾还含有许多非水溶性成分，可激活 AhR 途径。我们最近使用己烷可溶性烟草提取物进行的研究表明，AhR 通路的激活可能在烟草烟雾暴露引起的皮肤过早老化中发挥作用。
Although it is now widely recognized that tobacco smoke has negative effects on the skin, the molecular mechanisms underlying its skin-aging effects remain uncertain. Epidemiological studies indicate that tobacco smoking is a strong independent predictor of facial wrinkle formation and other aspects of premature skin aging. Recent in vivo studies in humans and mice provided the first direct evidence that tobacco smoke causes premature skin aging, and they have begun to reveal the molecular changes in the skin that occur in response to it. Water-soluble tobacco smoke extract, which predominantly produces oxidative stress when applied topically to cultured skin fibroblasts, impairs collagen biosynthesis. Matrix metalloproteinases, which degrade collagen, are induced dose-dependently by tobacco smoke extract as well as by other constituents that trigger the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that mediates the toxicity of several environmental contaminants, including photoproducts in the body generated by UVB radiation. Tobacco smoke also contains many non-water-soluble constituents that activate the AhR pathway. Our most recent studies using hexane-soluble tobacco extract indicate that activation of the AhR pathway may play a role in the premature skin-aging effects of tobacco smoke exposure.