A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16
A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16
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DOI：
10.1038/sj.mp.4002140
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发表时间：
2008-05-01
影响因子：
11
通讯作者：
Faraone, S. V.
中科院分区：
文献类型：
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作者：
Asherson, P.;Zhou, K.;Faraone, S. V.
作为国际多中心ADHD遗传学项目的一部分，我们完成了对142对狭义定义的精神障碍诊断和统计手册的受影响同胞对的研究，第四版组合型注意缺陷多动障碍(ADHD)先证者-兄弟姐妹对。在大多数已建立的与ADHD连锁的基因组区域5p和17p上未观察到连锁。我们分别在9号和16号染色体上发现了提示连锁信号，其中最高的多点非参数连锁信号位于染色体16q23上的99 cM(LOG of the Ods，LOD=3.1)，与先前发表的加州大学洛杉矶分校(LOD>；1，类似于95 cM)和荷兰LOD>；1，类似于100 cM的研究数据重叠。这项研究中的第二高峰位于染色体9q22的90 cM处(LOD=2.13)；之前加州大学洛杉矶分校和德国的研究也发现了一些几乎相同位置的连锁证据(加州大学洛杉矶分校的LOD=1.45，93 cM；德国的LOD=0.68,100 cM)。这两个主峰与先前发现的重叠表明，与ADHD相关的基因座可能位于这些区域。对所有可用的ADHD连锁扫描数据的原始数据进行荟萃分析或重新分析可能有助于澄清这些数据是否代表真实的连锁基因座。
As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband-sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99cM (log of the odds, LOD= 3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD > 1, similar to 95 cM) and Dutch LOD > 1, similar to 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90cM (LOD = 2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD= 1.45 at 93 cM; German LOD= 0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci.