Neural Stem Cells Maintain Their Stemness through Protein Kinase C ζ-Mediated Inhibition of TRIM32
Neural Stem Cells Maintain Their Stemness through Protein Kinase C ζ-Mediated Inhibition of TRIM32
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DOI：
10.1002/stem.687
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发表时间：
2011-09-01
期刊：
影响因子：
5.2
通讯作者：
Schwamborn, Jens C.
中科院分区：
文献类型：
--
作者：
Hillje, Anna-Lena;Worlitzer, Maik M. A.;Schwamborn, Jens C.
过去几年的一些研究已经深入了解了驱动神经元分化的机制。然而，确保神经干细胞在几轮细胞分裂中保持干细胞特性的机制在很大程度上仍然是未知的。在这里，我们提供的证据表明，神经元的命运决定簇TRIM 32结合蛋白激酶C ζ。通过这种相互作用，TRIM 32保留在细胞质中。然而，在分化过程中，这种相互作用被废除，TRIM 32易位到细胞核，通过靶向c-Myc进行蛋白酶体降解来启动神经元分化。干细胞2011;29：1437-1447
Several studies over the last couple of years have delivered insights into the mechanisms that drive neuronal differentiation. However, the mechanisms that ensure the maintenance of stemness characteristics in neural stem cells over several rounds of cell divisions are still largely unknown. Here, we provide evidence that the neuronal fate determinant TRIM32 binds to the protein kinase C zeta. Through this interaction, TRIM32 is retained in the cytoplasm. However, during differentiation, this interaction is abrogated and TRIM32 translocates to the nucleus to initiate neuronal differentiation by targeting c-Myc for proteasomal degradation. STEM CELLS 2011;29:1437-1447