Engineering Three-Dimensional Vascularized Cardiac Tissues.
Engineering Three-Dimensional Vascularized Cardiac Tissues.
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DOI：
10.1089/ten.teb.2020.0343
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发表时间：
2021-02
期刊：
影响因子：
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通讯作者：
M. A. C. Williams;Devin B. Mair;Wonjae Lee;Esak Lee;Deok‐Ho Kim
中科院分区：
文献类型：
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作者：
M. A. C. Williams;Devin B. Mair;Wonjae Lee;Esak Lee;Deok‐Ho Kim
心脏病是全世界人类健康的最大负担之一，治疗选择非常有限。工程化三维（3D）血管化心脏组织在挽救患病心脏的心脏功能方面显示出希望，并且可能在未来作为整个器官的替代品。将这些厚心肌组织重建到临床适用规模的主要障碍之一是能够在整个工程构建体中提供氧气和营养的功能性血管网络的整合。如果没有氧气和营养物质流灌注到整个工程组织，不仅组织活力会受到损害，而且整体组织功能也会丧失。目前已经开发出许多支持技术和方法来创建血管网络，例如 3D 生物打印、共培养水凝胶以及掺入可溶性血管生成因子。在这篇最先进的综述中，我们讨论了文献中报道的一些最新的工程血管心脏组织以及该领域的未来方向。
Heart disease is one of the largest burdens to human health worldwide and has very limited therapeutic options. Engineered three-dimensional (3D) vascularized cardiac tissues have shown promise in rescuing cardiac function in diseased hearts and may serve as a whole organ replacement in the future. One of the major obstacles in reconstructing these thick myocardial tissues to a clinically applicable scale is the integration of functional vascular networks capable of providing oxygen and nutrients throughout whole engineered constructs. Without perfusion of oxygen and nutrient flow throughout the entire engineered tissue, not only is tissue viability compromised, but overall tissue functionality is lost. There are many supporting technologies and approaches that have been developed to create vascular networks such as 3D bioprinting, co-culturing hydrogels, and incorporation of soluble angiogenic factors. In this state-of-the-art review we discuss some of the most current engineered vascular cardiac tissues reported in the literature and future directions in the field.