Serum bone turnover markers may be involved in the metastatic potential of lung cancer patients
Serum bone turnover markers may be involved in the metastatic potential of lung cancer patients
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DOI：
10.1007/s12032-009-9214-z
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发表时间：
2010-06-01
期刊：
影响因子：
3.4
通讯作者：
Syrigos, Kostas N.
中科院分区：
文献类型：
--
作者：
Karapanagiotou, Eleni M.;Terpos, Evangelos;Syrigos, Kostas N.
本研究的目的是研究非小细胞肺（NSCLC）和小细胞肺（SCLC）患者中发生或未发生继发性骨病的几种骨标志物。在22例有骨转移的NSCLC患者、18例无骨转移的NSCLC患者和28例SCLC患者中测定了空腹血清骨形成、骨吸收和破骨细胞生成标志物水平。共有29名健康志愿者也被纳入研究。NCLC伴骨转移患者血清骨钙素（OC）水平降低，骨桥蛋白和核因子κ B受体配体（RANKL）水平升高; SCLC患者血清I型胶原C端交联端肽水平升高，RANKL/OPG（osteoprotegerin）比值升高。在所有肺癌患者中观察到血清OPG水平升高。OPG在肺癌转移过程中起重要作用。此外，NSCLC患者的OC、OPN和RANKL以及SCLC患者的CTX和RANKL也可能在肺癌的发病机制和扩散中发挥更广泛的作用。它们还提供了有用的信息，以确定可能受益于更严格的治疗的患者群体。
The aim of this study was to investigate several bone markers in Non-Small Cell Lung (NSCLC) and Small Cell Lung (SCLC) patients experiencing or not secondary bony disease. Fasting serum levels of bone formation, bone resorption, and osteoclastogenesis markers were determined in 22 NSCLC patients with bone metastases, 18 without bone metastasis, and 28 SCLC patients. A total of 29 healthy volunteers were also included in the study. Decreased osteocalcin (OC) serum levels and increased osteopontin and ligand of the receptor of nuclear factor kB (RANKL) serum levels were detected in NCSLC patients with bone metastases while increased C-terminal cross-linking telopeptide of type I collagen and increased RANKL/OPG (osteoprotegerin) ratio were detected in SCLC patients. Increased serum levels of OPG were observed in all lung cancer patients. OPG may be actively involved in the development of lung cancer metastasis. Furthermore, OC, OPN, and RANKL in NSCLC and CTX and RANKL in SCLC patients may also have a broader role in the pathogenesis and spread of lung cancer. They also provide useful information in identifying the group of patients that may benefit from a more rigorous treatment.