Multimodal neuroimaging dissociates hemodynamic and electrophysiological correlates of error processing
Multimodal neuroimaging dissociates hemodynamic and electrophysiological correlates of error processing
复制标题
DOI：
10.1073/pnas.1103475108
复制
发表时间：
2011-10-18
影响因子：
11.1
通讯作者：
Manoach, Dara S.
中科院分区：
文献类型：
--
作者：
Agam, Yigal;Haemaelaeinen, Matti S.;Manoach, Dara S.
识别错误和调整反应是适应性行为的基础。背侧前扣带皮层 (dACC) 的错误相关负性 (ERN) 和错误相关功能 MRI (fMRI) 激活索引了这些过程，并被认为反映了相同的神经机制。在本研究中，我们评估了这一假设。尽管使用 fMRI 时错误会引起 dACC 的强烈激活，但结合脑电图和脑磁图数据将 ERN 定位于后扣带皮层 (PCC)。 ERN 幅度与 PCC 和 dACC 中的 fMRI 激活相关，并且这两个区域显示出基于功能连接 MRI 的协调活动。最后，通过扩散张量成像测量，后扣带束微观结构完整性的增加预示着更快的误差校正。这些发现表明 PCC 生成 ERN 并与 dACC 通信以促进错误处理。他们挑战了当前的模型，该模型将 dACC 的 fMRI 激活视为 ERN 的血流动力学反映。
Recognizing errors and adjusting responses are fundamental to adaptive behavior. The error-related negativity (ERN) and error-related functional MRI (fMRI) activation of the dorsal anterior cingulate cortex (dACC) index these processes and are thought to reflect the same neural mechanism. In the present study, we evaluated this hypothesis. Although errors elicited robust dACC activation using fMRI, combined electroencephalography and magnetoencephalography data localized the ERN to the posterior cingulate cortex (PCC). ERN amplitude correlated with fMRI activation in both the PCC and dACC, and these two regions showed coordinated activity based on functional connectivity MRI. Finally, increased microstructural integrity of the posterior cingulum bundle, as measured by diffusion tensor imaging, predicted faster error correction. These findings suggest that the PCC generates the ERN and communicates with the dACC to subserve error processing. They challenge current models that view fMRI activation of the dACC as the hemodynamic reflection of the ERN.