Relations of plasma homocysteine to left ventricular structure and function:: the Framingham Heart Study
Relations of plasma homocysteine to left ventricular structure and function:: the Framingham Heart Study
复制标题
DOI：
10.1016/j.ehj.2004.01.008
复制
发表时间：
2004-03-01
影响因子：
39.3
通讯作者：
Vasan, RS
中科院分区：
文献类型：
--
作者：
Sundströma, J;Sullivan, L;Vasan, RS
高同型半胱氨酸血症是充血性心力衰竭的危险因素，尤其是女性。我们调查，如果同型半胱氨酸促进左心室（LV）remodeling.Methods和结果，我们研究了横截面的关系，血浆总同型半胱氨酸超声心动图左心室的结构和功能在2697心脏研究参与者（平均年龄58岁，58%的妇女）的心力衰竭和以前的心肌梗死。校正年龄和身高后，女性血浆同型半胱氨酸与左室质量、室壁厚度和相对室壁厚度呈正相关（p = 0.0004-0.04），但男性血浆同型半胱氨酸与左室质量、室壁厚度和相对室壁厚度无关（p = 0.28-0.68）。另外调整其他临床协变量后，女性血浆同型半胱氨酸与左室质量和室壁厚度的关系仍具有统计学显著性，但与相对瓦特厚度的关系具有临界显著性（对于ln[同型半胱氨酸]增加1-SD，分别增加1.92 g、0.01 cm和0.29%，p = 0.01-0.08）。在所有女性模型中，血浆同型半胱氨酸的第四个四分位数的左心室质量和瓦特厚度均高于较低的三个四分位数（p = 0.0003-0.02），但在男性中并非如此（p = 0.25-0.78）。血浆同型半胱氨酸水平与左房无关。结论在我们的社区为基础的样本中，血浆同型半胱氨酸是直接相关的左心室质量和壁厚的女性，但在男性中没有。(C)2004年欧洲心脏病学会。由爱思唯尔有限公司出版。保留所有权利。
Aims Hyperhomocysteinaemia is a risk factor for congestive heart failure, especially in women. We investigated if homocysteine promotes left ventricular (LV) remodelling.Methods and results We examined cross-sectional relations of plasma total homocysteine to echocardiographic LV structure and function in 2697 Framingham Heart Study participants (mean age 58 years, 58% women) free of heart failure and previous myocardial infarction. Adjusting for age and height, plasma homocysteine was positively related to LV mass, wall thickness, and relative wall thickness in women (p = 0.0004-0.04), but not in men (p = 0.28-0.68). Adjusting additionally for other clinical covariates, the relations of plasma homocysteine to LV mass and wall thickness in women remained statistically significant, but the relation to relative watt thickness became of borderline significance (1.92 g, 0.01 cm, and 0.29% increase, respectively, for a 1-SD increase in ln[homocysteine], p = 0.01-0.08). LV mass and watt thickness were higher in the fourth quartile of plasma homocysteine compared to the lower three in all models in women (p = 0.0003-0.02), but not in men (p = 0.25-0.78). Plasma homocysteine was not related to left atrial. size or LV fractional shortening in either sex.Conclusion In our community-based sample, plasma homocysteine was directly related to LV mass and wall thickness in women but not in men. (C) 2004 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.