Two cases of short QT interval
Two cases of short QT interval
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DOI：
10.1111/j.1540-8159.2007.00901.x
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发表时间：
2007-12-01
影响因子：
1.8
通讯作者：
Akahoshi, Masazumi
中科院分区：
文献类型：
--
作者：
Moriya, Manabu;Seto, Shinji;Akahoshi, Masazumi
背景：短QT间期的流行病学尚不清楚。我们试图确定短QT间期的发生率和临床特征在纵向cohort study.Methods：共有19,153例受试者（7,525名男性，11,628名女性）参加了这项研究，所有可用的心电图（ECG）进行了纵向调查，从1958年到2003年。我们将短QT间期定义为QTc小于350 ms.Results：在19，153例受试者中，有2例符合短QT间期标准，短QT间期的患病率和发生率估计分别为0.01%和0.39/100，000人-年。两例病例均无心脏性猝死家族史，也无可能影响QT间期的药物使用史。例1为女性，有缺血性心脏病史。病例2为60岁男性，26岁时首次出现短QT间期。结论：在这项研究的19,153名受试者中，没有人被确定为具有短QT综合征，与室性快速性心律失常，心房颤动和猝死的高风险。确定2例受试者的QTc小于350 ms，并允许估计短QT间期的患病率和发生率。这些观察结果提示了短QT间期与器质性或电生理性心脏病之间的临床关系。
Background: The epidemiology of short QT interval remains unclear. We attempted to determine the incidence and clinical characteristics of short QT interval in a longitudinal cohort study.Methods: A total of 19,153 subjects (7,525 male, 11,628 female) were enrolled in the study and all available electrocardiograms (ECGs) were investigated longitudinally from 1958 through 2003. We defined short QT interval as QTc of less than 350 ms.Results: Of the 19,153 subjects, two met the criteria of short QT interval and allowed for prevalence and incidence estimates for short QT interval as 0.01% and 0.39/100,000 person-years, respectively. Both cases had neither a family history of sudden cardiac death, nor a history of drug use that might have affected for QT interval. Case 1 was a female with history of ischemic heart disease. Case 2 was a 60-year-old male who exhibited a short QT interval for the first time when he was 26 years of age. He had sick sinus syndrome as an underlying heart disease.Conclusions: Of the 19,153 subjects in this study, none were identified as having the short QT syndrome, with associated high risk of ventricular tachyarrhythmia, atrial fibrillation, and sudden death. Two subjects were identified as having QTc of less than 350 ms, and allowed prevalence and incidence estimates to be made of short QT interval. There observations were suggestive of clinical relationships between short QT interval and organic or electrophysiological heart disease.