Cholecystokinin-58 is more potent in inhibiting food intake than cholecystokinin-8 in rats
Cholecystokinin-58 is more potent in inhibiting food intake than cholecystokinin-8 in rats
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DOI：
10.1179/147683008x301432
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发表时间：
2008-04-01
影响因子：
3.6
通讯作者：
Zittel, Tilman T.
中科院分区：
文献类型：
--
作者：
Glatzle, Joerg;Raybould, Helen E.;Zittel, Tilman T.
Introduction: Several cholecystokinin (CCK) forms have been detected in plasma, but most studies on food intake investigated the effects of CCK-8 only. Recently, it has been demonstrated that CCK-58 is the only endocrine-active form of CCK in rats.Methods: CCK-58 was synthesized with a peptide synthesizer using FMOC chemistry and CCK-58 effects on food intake were compared to CCK-8 in rats.Results: Both CCK-58 and CCK-8 inhibited food intake in a dose-dependent manner and were equally potent at vs min. CCK-58 showed a prolonged inhibition of food intake compared to CCK-8 at the higher dose tested (7 nmol/kg), inhibiting food intake also at 60 min, and cumulative food intake was inhibited for up to 210 min by CCK-58.Conclusions: CCK-58 has the same potency in inhibiting food intake as CCK-8 in rats, but inhibits food intake longer. This might be due to its tertiary structure resulting in a delayed plasma degradation or a prolonged binding at the CCK receptor. As CCK-58 is the major CCK form in the gut wall and possibly in the circulating blood in humans, the effects of CCK on food intake might have been underestimated in the past.
