Multilocus Genetic Risk Scores for Coronary Heart Disease Prediction
Multilocus Genetic Risk Scores for Coronary Heart Disease Prediction
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DOI：
10.1161/atvbaha.113.301218
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发表时间：
2013-09-01
影响因子：
8.7
通讯作者：
Ingelsson, Erik
中科院分区：
文献类型：
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作者：
Ganna, Andrea;Magnusson, Patrik K. E.;Ingelsson, Erik
目前的指南不支持在冠心病（CHD）风险评估中使用遗传图谱。然而，新的单核苷酸多态性与冠心病和中间心血管性状最近被发现。我们的目的是比较几个多基因座遗传风险评分（MGRS）与冠心病的相关性，并评估临床use.Approach和Results-We调查了6瑞典前瞻性队列研究与10 612名参与者免费冠心病在基线。我们基于395个与心血管特征相关的单核苷酸多态性，开发了1个总体MGRS，1个CHD特异性MGRS，包括46个单核苷酸多态性，以及6个针对每个已确定CHD危险因素的特征特异性MGRS。总体和CHD特异性MGRS均与CHD风险显著相关（781起事件;第四与第一四分位数的风险比分别为1.54和1.52; P
Objective-Current guidelines do not support the use of genetic profiles in risk assessment of coronary heart disease (CHD). However, new single nucleotide polymorphisms associated with CHD and intermediate cardiovascular traits have recently been discovered. We aimed to compare several multilocus genetic risk score (MGRS) in terms of association with CHD and to evaluate clinical use.Approach and Results-We investigated 6 Swedish prospective cohort studies with 10 612 participants free of CHD at baseline. We developed 1 overall MGRS based on 395 single nucleotide polymorphisms reported as being associated with cardiovascular traits, 1 CHD-specific MGRS, including 46 single nucleotide polymorphisms, and 6 trait-specific MGRS for each established CHD risk factors. Both the overall and the CHD-specific MGRS were significantly associated with CHD risk (781 incident events; hazard ratios for fourth versus first quartile, 1.54 and 1.52; P