Tools to investigate the ubiquitin proteasome system.
Tools to investigate the ubiquitin proteasome system.
复制标题
研究泛素蛋白酶体系统的工具。
DOI：
10.1016/j.ddtec.2017.11.006
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发表时间：
2017-12-01
期刊：
影响因子：
--
通讯作者：
Ovaa, Huib
中科院分区：
文献类型：
--
作者：
Leestemaker, Yves;Ovaa, Huib
泛素是一种由76个氨基酸组成的调节蛋白，参与许多重要的细胞过程。通过E1、E2和E3酶的连续作用，泛素可以在赖氨酸残基或N-末端与其他蛋白质连接。泛素也可以连接到自身，产生聚泛素链。泛素化以不同的方式影响底物蛋白，例如通过导致底物蛋白被26 S蛋白酶体降解。泛素化可以被去泛素化酶逆转，去泛素化酶可以修剪或去除蛋白质中的泛素链。许多参与蛋白质的泛素化、去泛素化或降解的蛋白质与人类疾病有关，目前正作为潜在的药物靶点进行研究。
Ubiquitin is a 76-amino acid regulatory protein involved in many important cellular processes. Ubiquitin can be attached to other proteins at either a lysine residue or to the N-terminus by the consecutive actions of E1, E2, and E3 enzymes. Ubiquitin can also be attached to itself, resulting in poly-ubiquitin chains. Ubiquitination affects substrate proteins in different ways, for example by resulting in degradation of the substrate protein by the 26S proteasome. Ubiquitination can be reversed by deubiquitinating enzymes, which either trim or remove ubiquitin chains from proteins. Many proteins involved in either the ubiquitination, deubiquitination or degradation of proteins are implicated in human diseases and are currently under investigation as potential drug targets.