PENTAZOCINE . STRONG ANALGESICS + ANALGESIC ANTAGONISTS IN BENZOMORPHAN SERIES
PENTAZOCINE . STRONG ANALGESICS + ANALGESIC ANTAGONISTS IN BENZOMORPHAN SERIES
复制标题
DOI：
10.1021/jm00332a001
复制
发表时间：
1964-01-01
影响因子：
7.3
通讯作者：
HARRIS, LS
中科院分区：
文献类型：
--
作者：
ARCHER, S;PIERSO, NAK;HARRIS, LS
本文合成了一系列N-取代的5-烷基-2-羟基-9-甲基-6，7-苯并吗啉类化合物，并对其作为啮齿类动物镇痛拮抗剂的活性进行了评价，以期获得对人类有效的镇痛药物，并讨论了用这种方法分离强镇痛和成瘾倾向的基本原理。
A series of N-substituted 5-alkyl-2[image]-hydroxy-9-methyl-6,7-benzomorphans were synthesized and evaluated as analgesic antagonists in rodents in the hope of obtaining drugs which would be potent analgesics in man. The rationale for using this approach to the problem of separating strong analgesia from addiction liability is discussed.