SYSTEMIC VASCULAR CHANGES IN SPONTANEOUS OCCLUSION OF THE CIRCLE OF WILLIS
SYSTEMIC VASCULAR CHANGES IN SPONTANEOUS OCCLUSION OF THE CIRCLE OF WILLIS
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DOI：
10.1161/01.str.22.11.1358
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发表时间：
1991-11-01
期刊：
影响因子：
8.3
通讯作者：
IKEDA, E
中科院分区：
文献类型：
--
作者：
IKEDA, E
背景和目的：我们研究了引起所谓的“Willis环自发性闭塞”的血管变化的全身病因因素的存在。方法：对13例脑血管性烟雾病患者进行颅外血管形态学检查和形态计量学分析。颅外血管的组织病理学结果如下：1）与颅内血管相似的晚期内膜纤维增厚; 2）13例患者中3例患者肺动脉近端部分的特征性内膜纤维结节增厚，可能表明壁血栓的组织化。形态计量学分析显示肺动脉内膜明显增厚（p < 0.05），肾动脉（p < 0.05），胰腺动脉（p < 0.01）与年龄和性别匹配的对照组相比。根据这些发现，这种疾病很可能有全身性病因因素，以及局灶性病因因素，在颅内和颅外血管中产生血管变化。
Background and Purpose: We examined the presence of systemic etiologic factors causing vascular changes in so-called "spontaneous occlusion of the circle of Willis" (cerebrovascular moyamoya disease) to determine whether extracranial, as well as intracranial, vessels are involved in this disease.Methods: Histopathologic examination and morphometric analysis of the extracranial vessels were performed in 13 patients with this disease.Results: The histopathologic findings of the extracranial vessels were as follows: 1) advanced intimal fibrous thickening similar to that of the intracranial vessels; and 2) characteristic intimal fibrous nodular thickening, which may indicate organization of mural thrombi, at the proximal portions of the pulmonary arteries in three of 13 patients. Morphometric analysis revealed significant intimal thickening of the pulmonary arteries (p < 0.05), renal arteries (p < 0.05), and pancreatic arteries (p < 0.01) in patients with this disease as compared with age- and sex-matched control patients.Conclusions: On the basis of these findings, it is highly likely that this disease has systemic etiologic factors, as well as focal etiologic factors, that work to create vascular change in both the intracranial and extracranial vessels.