Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies
Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies
复制标题
休闲时间体力活动与癌症风险：基于 126 项高质量流行病学研究对世界卫生组织建议的评估
DOI：
10.1136/bjsports-2015-094728
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发表时间：
2016-03-01
影响因子：
18.4
通讯作者：
Wei, Sheng
中科院分区：
文献类型：
--
作者：
Liu, Li;Shi, Yun;Wei, Sheng
世界卫生组织（WHO）的结论是，身体活动可以降低许多疾病的风险。然而，很少有系统的审查已经进行了评估的作用，休闲时间的体力活动（LTPA）在降低癌症的风险，在剂量依赖性的方式，并进一步的身体活动的建议，由世界卫生组织的适用性。方法采用系统评价和荟萃分析的方法，以二项比较和剂量依赖的方式评估LTPA的癌症风险。检索了截至2014年12月30日的MEDLINE和Web of Science，无语言限制。审查参考文献列表中的潜在文章。结果共纳入126篇文献。总的来说，与那些做得最少的人相比，做得最多的人的总癌症风险降低了10%。剂量反应荟萃分析表明，目前WHO推荐的剂量（相当于每周平均10个代谢当量能量小时）可使癌症减少7%（95% CI 5%至9%）。此外，LTPA对癌症的保护作用在每周20代谢当量能量小时时达到饱和，相对风险为0.91（95%CI 0.88至0.93）。基于癌症类型的亚分析结果显示，LTPA仅对乳腺癌和结直肠癌具有显着的保护作用。结论我们的荟萃分析表明，目前WHO推荐的体力活动可以导致癌症风险降低7%，这主要归因于其对乳腺癌和结直肠癌的保护作用。此外，目前推荐水平的两倍被认为是对癌症的饱和保护。
Background The WHO has concluded that physical activity reduces the risk of numerous diseases. However, few systemic reviews have been performed to assess the role of leisure time physical activity (LTPA) in lowering the risk of cancer in a dose-dependent manner and furthermore the suitability of recommendation of physical activity by the WHO. Methods A systematic review and meta-analysis was designed to estimate cancer risk by LTPA in binary comparison and in a dose-dependent manner. MEDLINE and Web of Science were searched up to 30 December 2014 without language restrictions. Reference lists were reviewed for potential articles. Results A total of 126 studies were recruited into the meta-analysis. Overall, the total cancer risk was reduced by 10% in people who undertook the most LTPA as compared with those who did the least. Dose–response meta-analysis indicated that the current WHO recommendation (equal to an average of 10 metabolic equivalents of energy hours per week) induced a 7% (95% CI 5% to 9%) cancer reduction. Moreover, the protective role of LTPA against cancer becomes saturated at 20 metabolic equivalents of energy hours per week, with a relative risk of 0.91 (95% CI 0.88 to 0.93). Subanalyses results based on cancer types showed that LTPA only exhibited significant protection against breast cancer and colorectal cancer. Conclusions Our meta-analysis indicates that the current WHO recommendation of physical activity can result in a 7% reduction in cancer risk, which is mainly attributed to its protective role against breast cancer and colorectal cancer. Furthermore, two-fold of current recommendation level is considered to give its saturated protection against cancer.