Nitroxides as Antioxidants and Anticancer Drugs.
Nitroxides as Antioxidants and Anticancer Drugs.
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DOI：
10.3390/ijms18112490
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发表时间：
2017-11-22
影响因子：
5.6
通讯作者：
Gwozdzinski K
中科院分区：
文献类型：
--
作者：
Lewandowski M;Gwozdzinski K
硝基氧是稳定的自由基，含有带有不成对电子的硝酰基。在本文中，我们介绍了硝基氧作为抗氧化剂和抗癌药物的特性和应用。生物学和医学中最常用的硝基氧是哌啶、吡咯啉和吡咯烷的一组杂环硝基氧衍生物。硝基氧的抗氧化作用与其氧化还原循环有关。与其他抗氧化剂不同，氮氧化物的特征在于与单电子氧化和还原反应相关的催化作用机制。在生物条件下，它们模仿超氧化物歧化酶（SOD），调节血红素蛋白的过氧化氢酶样活性，清除反应性自由基，抑制芬顿和哈伯-韦斯反应并抑制生物材料（肽、蛋白质、脂质等）的氧化。还研究了使用硝基氧作为抗氧化剂来对抗抗癌药物引起的氧化应激。通过体内和体外实验，讨论了硝基氧及其衍生物作为抗癌药物在乳腺癌、肝癌、肺癌、卵巢癌、淋巴癌和甲状腺癌中的应用。在本文中，我们重点关注新型天然自旋标记衍生物，如喜树碱、鱼藤酮、考布他汀、鬼臼毒素等。还讨论了硝基氧在衰老过程、心血管疾病和病理状况中的应用。
Nitroxides are stable free radicals that contain a nitroxyl group with an unpaired electron. In this paper, we present the properties and application of nitroxides as antioxidants and anticancer drugs. The mostly used nitroxides in biology and medicine are a group of heterocyclic nitroxide derivatives of piperidine, pyrroline and pyrrolidine. The antioxidant action of nitroxides is associated with their redox cycle. Nitroxides, unlike other antioxidants, are characterized by a catalytic mechanism of action associated with a single electron oxidation and reduction reaction. In biological conditions, they mimic superoxide dismutase (SOD), modulate hemoprotein’s catalase-like activity, scavenge reactive free radicals, inhibit the Fenton and Haber-Weiss reactions and suppress the oxidation of biological materials (peptides, proteins, lipids, etc.). The use of nitroxides as antioxidants against oxidative stress induced by anticancer drugs has also been investigated. The application of nitroxides and their derivatives as anticancer drugs is discussed in the contexts of breast, hepatic, lung, ovarian, lymphatic and thyroid cancers under in vivo and in vitro experiments. In this article, we focus on new natural spin-labelled derivatives such as camptothecin, rotenone, combretastatin, podophyllotoxin and others. The applications of nitroxides in the aging process, cardiovascular disease and pathological conditions were also discussed.
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影响因子：
3.7
作者：
Dickey JS;Gonzalez Y;Aryal B;Mog S;Nakamura AJ;Redon CE;Baxa U;Rosen E;Cheng G;Zielonka J;Parekh P;Mason KP;Joseph J;Kalyanaraman B;Bonner W;Herman E;Shacter E;Rao VA
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Rao VA
影响因子：
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作者：
BABIOR, BM
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Thiemermann, C
影响因子：
4.6
作者：
Deng, Yea-Tzy;Huang, Hsiu-Chen;Lin, Jen-Kun
通讯作者：
Lin, Jen-Kun