A prospective cohort study of bladder cancer risk in relation to active cigarette smoking and household exposure to secondhand cigarette smoke
A prospective cohort study of bladder cancer risk in relation to active cigarette smoking and household exposure to secondhand cigarette smoke
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DOI：
10.1093/aje/kwk047
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发表时间：
2007-03-15
影响因子：
5
通讯作者：
Comstock, George W.
中科院分区：
文献类型：
--
作者：
Alberg, Anthony J.;Kouzis, Anthony;Comstock, George W.
积极吸烟是膀胱癌的主要危险因素。二手接触香烟烟雾也可能导致膀胱癌发生。作者进行了一项前瞻性队列研究，以检查主动吸烟和家庭暴露于二手烟（SHS）对随后膀胱癌风险的影响。研究人群包括1963年（n = 45，749; 93例病例）和1975年（n = 48，172; 172例病例）在马里兰州华盛顿县进行的私人人口普查中建立的两个队列的受试者。Poisson回归模型被拟合以估计两个队列中与主动和被动吸烟暴露相关的膀胱癌的相对风险（参考类别：不与任何吸烟者生活在一起的从不吸烟者）。在调整年龄、教育和婚姻状况后，1963年队列（相对危险度（RR）= 2.7，95%置信限（CL）：1.6，4.7）和1975年队列（RR = 2.6，95% CL：1.7，3.9）中，目前吸烟者患膀胱癌的风险升高。在非吸烟女性中，1963年队列中当前家庭SHS暴露与膀胱癌风险相关（RR = 2.3，95%CL：1.0，5.4），但在1975年队列中则无关（RR = 0.9，95%CL：0.4，2.3）。这项研究进一步巩固了主动吸烟与膀胱癌有因果关系的证据。需要进一步的研究来确定被动吸烟是否是膀胱癌的危险因素。
Active cigarette smoking is a major risk factor for bladder cancer. Secondhand exposure to cigarette smoke may also contribute to bladder carcinogenesis. The authors conducted a prospective cohort study to examine the influence of both active smoking and household exposure to secondhand smoke (SHS) on subsequent bladder cancer risk. The study population included persons from two cohorts established from private censuses conducted in Washington County, Maryland, in 1963 (n = 45,749; 93 cases) and 1975 (n = 48,172; 172 cases). Poisson regression models were fitted to estimate the relative risk of bladder cancer associated with active and passive smoke exposure in the two cohorts (referent category: never smokers who did not live with any smokers). Current smokers had an elevated risk of bladder cancer in both the 1963 cohort (relative risk (RR) = 2.7, 95% confidence limits (CL): 1.6, 4.7) and the 1975 cohort (RR = 2.6, 95% CL: 1.7, 3.9) after adjustment for age, education, and marital status. Among nonsmoking women, current household SHS exposure was associated with bladder cancer risk in the 1963 cohort (RR = 2.3, 95% CL: 1.0, 5.4) but not in the 1975 cohort (RR = 0.9, 95% CL: 0.4, 2.3). This study further solidifies the evidence that active smoking is causally associated with bladder cancer. Additional studies are needed to determine whether passive smoking is a risk factor for bladder cancer.