Lipid abnormalities and renal disease: Is dyslipidemia a predictor of progression of renal disease?
Lipid abnormalities and renal disease: Is dyslipidemia a predictor of progression of renal disease?
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DOI：
10.1097/00000441-200306000-00005
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发表时间：
2003-06-01
影响因子：
3.1
通讯作者：
Taylor, HA
中科院分区：
文献类型：
--
作者：
Crook, ED;Thallapureddy, A;Taylor, HA
血脂异常是心血管疾病(CVD)的危险因素，与动脉粥样硬化和斑块不稳定性增强有关。在慢性肾功能衰竭的早期和晚期，肾功能不全与脂蛋白代谢异常有关。这些变化包括载脂蛋白A(ApoA)和含有β的脂蛋白、高密度脂蛋白和甘油三酯的变化。在动物模型中，这些脂质代谢和作用的改变导致巨噬细胞激活和肾脏的渗透，从而导致肾小管间质和内皮细胞损伤。有限的人类数据表明，除了导致心血管疾病外，血脂异常可能是肾脏疾病进展的风险因素。血脂异常对肾脏的影响主要见于有其他肾脏疾病进展危险因素的患者，如高血压、糖尿病和蛋白尿。肾脏疾病是心血管疾病的强烈风险因素，而非裔美国人患肾脏疾病的比例很高。因此，研究血脂异常对肾脏疾病的发展或进展的影响将是杰克逊心脏研究的一个重要问题，也是本综述的主题。
Dyslipidemia is a cardiovascular disease (CVD) risk factor that is associated with enhanced atherosclerosis and plaque instability. Renal insufficiency is associated with abnormalities in lipoprotein metabolism in both the early and the advanced stages of chronic renal failure. These include alterations in apolipoprotein A (apo A)- and beta- containing lipoproteins, high-density lipoproteins, and triglycerides. in animal models, these alterations in lipid metabolism and action lead to macrophage activation and infiltration in the kidney with resultant tubulointerstitial and endothelial cell injury. Limited data in humans suggest that, in addition to contributing to CVD, dyslipidemia may be a risk factor for the progression of renal disease. The effects of dyslipidemia on the kidney are mainly observed in those with other risk factors for renal disease progression such as hypertension, diabetes, and proteinuria. Renal disease is a strong risk factor for CVD and African Americans have high rates of renal disease. Therefore, examining the effects of dyslipidemia on the development or progression or renal disease will be an important question for the Jackson Heart Study and is the topic of this review.