Intralitter transmission of haemophilus influenzae type b in infant rats and rifampin eradication of nasopharyngeal colonization.
Intralitter transmission of haemophilus influenzae type b in infant rats and rifampin eradication of nasopharyngeal colonization.
复制标题
幼鼠体内 B 型流感嗜血杆菌的体内传播和利福平根除鼻咽定植。
DOI：
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发表时间：
1980
影响因子：
6.4
通讯作者：
M. Glodé
中科院分区：
文献类型：
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作者：
N. Halsey;C. Korock;T. Johansen;M. Glodé
研究了幼年大鼠中B型流感嗜血杆菌的鼻咽定植、菌血症和感染传播的动力学。鼻内接种导致99%的幼鼠出现鼻内定植，88%的幼鼠出现菌血症。H. B型流感病毒传播给93%的暴露、未接种的同窝仔。用驴抗H. B型流感病毒可预防菌血症，但不能预防鼻腔定植。利福平20 mg/kg，每日2次，连用2天，对两株H.鼻咽部的B型流感病毒。10 mg/kg每日2次和5 mg/kg每日2次连续2天的有效率分别为86%和6%。在利福平治疗后仍定殖的动物中未发现利福平耐药分离株。该模型的嗜血杆菌定植和intralitter传输可用于评估其他化学预防剂，并可能提供更多的了解嗜血杆菌感染的流行病学和免疫学。
The dynamics of nasopharyngeal colonization, bacteremia, and transmission of infection due to Haemophilus influenzae type b in infant rats were studied. Intranasal inoculation resulted in nasal colonization in 99% and bacteremia in 88% of infant rats. H. influenzae type b was transmitted to 93% of exposed, uninoculated littermates. Pretreatment with burro antibody to H. influenzae type b prevented bacteremia but not nasal colonization. Rifampin, in a dose of 20 mg/kg twice daily for two days, was 97% and 100% effective in eradicating two strains of H. influenzae type b from the nasopharynx. Efficacies of 10 mg/kg twice daily and 5 mg/kg twice daily for two days were 86% and 6%, respectively. No rifampin-resistant isolates were encountered in animals still colonized after rifampin therapy. This model for haemophilus colonization and intralitter transmission could be used to evaluate other chemoprophylactic agents and may provide additional insight into the epidemiology and immunology of haemophilus infections.