Functional magnetic resonance imaging during pantomiming tool-use gestures
Functional magnetic resonance imaging during pantomiming tool-use gestures
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DOI：
10.1007/s002210100777
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发表时间：
2001-08-01
影响因子：
2
通讯作者：
Na, DG
中科院分区：
文献类型：
--
作者：
Choi, SH;Na, DL;Na, DG
本研究的目的是确定激活的功能领域有关的手势动作。使用功能性磁共振成像（fMRI），我们绘制了10个右撇子，正常志愿者在激活和控制任务的大脑活动。激活条件包括用左手或右手做手势，而控制条件包括拇指和食指之间重复的对立运动。激活的皮质区域高度偏侧化的左半球在哑剧的工具使用，无论使用的手。用任何一只手练习通常激活了上级顶叶、辅助运动区、左半球的运动前区和小脑蚓部。然而，最低限度的激活发生在顶下小叶，这已被称为是一个关键领域的实践产生。与左手练习相比，右手练习在左壳核和左下颞区后部表现出额外的激活。我们的研究结果与神经心理学的观察结果一致，右撇子的左半球介导编程和执行熟练的动作，在左半球，实践主要是subserved顶叶，辅助运动区，和运动前区。然而，与以前的病变研究，我们的功能磁共振成像研究的结果表明，上级顶叶小叶比下层顶叶小叶更可能发挥重要作用，在手势的生产。
The purpose of this study was to identify the functional fields activated in relation to gestural movements. Using functional magnetic resonance imaging (fMRI), we mapped brain activity in ten right-handed, normal volunteers during activation and control tasks. The activation condition consisted of pantomiming tool-use gestures with either the left hand or right hand, whereas the control condition comprised repetitive, oppositional movements between thumb and index finger. Activated cortical regions were highly lateralized to the left hemisphere during pantomiming of tool use regardless of hand used. Praxis with either hand commonly activated the superior parietal lobule, supplementary motor area, premotor area of the left hemisphere, and cerebellar vermis. However, minimal activation occurred in the inferior parietal lobule, which has been known to be a critical area for praxis generation. Compared with left-hand praxis, right-hand praxis exhibited additional activation in the left putamen and posterior part of the left inferior temporal region. Our findings concur with neuropsychological observations that the left hemisphere in right-handers mediates programming and executing skilled movements and that, within the left hemisphere, praxis is predominantly subserved by the parietal lobe, supplementary motor area, and premotor area. However, unlike previous lesion studies, the results of our fMRI study suggested that the superior parietal lobule more likely than the inferior parietal lobule play an important role in gesture production.