Effects of excitatory amino acids on dopamine synthesis in the rat retina.
Effects of excitatory amino acids on dopamine synthesis in the rat retina.
复制标题
兴奋性氨基酸对大鼠视网膜多巴胺合成的影响。
DOI：
10.1016/0014-2999(83)90120-6
复制
发表时间：
1983
影响因子：
5
通讯作者：
Morgan,WW
中科院分区：
文献类型：
--
作者：
Kamp,CW;Morgan,WW
眼内注射喹乙醇而不是N-甲基-D-天冬氨酸或海人酸能增加黑暗维持大鼠视网膜中多巴胺的合成。Quisquate的作用呈剂量依赖关系，但不能被谷氨酸拮抗剂谷氨酸二乙酯阻断。这些结果首次表明，暗适应大鼠视网膜中静止的多巴胺神经元可以被一种可能的内源性神经递质谷氨酸的兴奋性氨基酸类似物激活。
Intraocular administration of quisqualate but not of N-methyl-D-aspartate or kainate augments dopamine synthesis in the retinas of dark-maintained rats. The effect of quisqualate is dosage-dependent but not blocked by the glutamate antagonist, glutamate diethyl ester. These results are the first to show that the quiescent dopamine neurons of the dark-adapted rat retina can be activated by an excitatory amino acid analogue of the putative endogenous neurotransmitter, glutamate.