Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease
Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease
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DOI：
10.1016/j.bpg.2017.09.004
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发表时间：
2017-10-01
影响因子：
3.2
通讯作者：
Lagergren, Jesper
中科院分区：
文献类型：
--
作者：
Ness-Jensen, Eivind;Lagergren, Jesper
胃食管反流病（GORD）的发展时，胃内容物反流引起麻烦的症状或并发症。主要症状为烧心和反酸，并发症包括食管炎、狭窄、巴雷特食管和食管腺癌。除了遗传影响，GORD与生活方式因素有关，主要是肥胖。吸烟被认为是CORD的病因学因素，而饮酒被认为是反流发作的触发因素，而不是因果因素。然而，吸烟和饮酒都可以降低下食管括约肌压力，促进反流。此外，吸烟减少了富含碳酸氢盐的唾液的产生，这对缓冲和清除食管中的酸很重要。酒精对食管粘膜也有直接的有害作用，易造成酸性损伤。戒烟可降低CORD症状的风险，并鼓励饮酒引发反流的个体避免饮酒。(C)2017爱思唯尔有限公司版权所有
Gastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include oesophagitis, strictures, Barrett's oesophagus and oesophageal adenocarcinoma. In addition to hereditary influence, GORD is associated with lifestyle factors, mainly obesity. Tobacco smoking is regarded as an aetiological factor of CORD, while alcohol consumption is considered a triggering factor of reflux episodes and not a causal factor. Yet, both tobacco smoking and alcohol consumption can reduce the lower oesophageal sphincter pressure, facilitating reflux. In addition, tobacco smoking reduces the production of saliva rich in bicarbonate, which is important for buffering and clearance of acid in the oesophagus. Alcohol also has a direct noxious effect on the oesophageal mucosa, which predisposes to acidic injury. Tobacco smoking cessation reduces the risk of CORD symptoms and avoidance of alcohol is encouraged in individuals where alcohol consumption triggers reflux. (C) 2017 Elsevier Ltd. All rights reserved.