Breast ultrasound tomography versus MRI for clinical display of anatomy and tumor rendering: preliminary results.
Breast ultrasound tomography versus MRI for clinical display of anatomy and tumor rendering: preliminary results.
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DOI：
10.2214/ajr.11.6910
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Lupinacci J
中科院分区：
文献类型：
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作者：
Ranger B;Littrup PJ;Duric N;Chandiwala-Mody P;Li C;Schmidt S;Lupinacci J
确定超声断层扫描（UST）原型相对于磁共振（MR）的临床显示阈值，以便对乳腺解剖结构和肿瘤渲染进行可比可视化。本研究符合HIPAA，经IRB批准，并在获得知情同意后进行。36名妇女与MR和我们的UST原型成像。UST扫描生成反射、声速和衰减图像。将反射图像与声速和衰减图像的分量融合，所述声速和衰减图像实现阈值以使用图像算术处理来表示实质和/或固体质量。MR和UST临床图像的定性和定量比较用于识别解剖相似性，并优化肿瘤形状和体积的阈值。超声造影技术生成的UST图像可与MR相比，用于显示纤维间质、实质、脂肪组织和肿瘤，其中25例为癌症，11例为良性。经鉴定，1.46±0.1 km/s和1.52±0.03 km/s的优化声速阈值分别最能代表纤维腺体组织和实体肿块的范围。使用0.16±0.04 dB/cm的阈值的衰减图像的算术组合进一步表征了良恶性肿块。使用这些通用阈值，超声或MR检查的良性或恶性肿块的肿瘤体积无显著差异（p>0.1）。UST表现出以与MR相当的方式对乳腺组织进行成像和渲染的能力。通用UST阈值对于渲染良性和恶性组织的大小和分布似乎是可行的，而无需静脉内造影剂。
To determine the clinical display thresholds of an ultrasound tomography (UST) prototype relative to magnetic resonance (MR) for comparable visualization of breast anatomy and tumor rendering. The study was compliant with HIPAA, approved by the IRB, and performed after obtaining informed consent. Thirty-six women were imaged with MR and our UST prototype. The UST scan generated reflection, sound speed and attenuation images. The reflection images were fused with the components of sound speed and attenuation images that achieved thresholds to represent parenchyma and/or solid masses using an image arithmetic process. Qualitative and quantitative comparisons of MR and UST clinical images were used to identify anatomical similarities, and optimized thresholds for tumor shapes and volumes. Thresholding techniques generated UST images comparable to MR for visualizing fibrous stroma, parenchyma, fatty tissues, and tumors, of which 25 were cancer and 11 benign. Optimized sound speed thresholds of 1.46±0.1 km/s and 1.52±0.03 km/s were identified to best represent the extent of fibroglandular tissue and solid masses, respectively. An arithmetic combination of attenuation images using the threshold of 0.16±0.04 dB/cm further characterized benign from malignant masses. No significant difference in tumor volume was noted between benign or malignant masses by UST or MR (p>0.1) using these universal thresholds. UST demonstrated the ability to image and render breast tissues in a manner comparable to MR. Universal UST threshold values appear feasible for rendering of the size and distribution of benign and malignant tissues without intravenous contrast.