Retinopathy of prematurity and maternal age.
Retinopathy of prematurity and maternal age.
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DOI：
10.1097/iae.0b013e3181ba246f
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Shih CP
中科院分区：
文献类型：
--
作者：
Wu WC;Ong FS;Kuo JZ;Lai CC;Wang NC;Chen KJ;Hwang YS;Chen TL;Shih CP
确定与早产儿发生早产儿视网膜病变（ROP）相关的危险因素，尤其是母亲危险因素。回顾性地进行了一项涉及早产患者的匹配病例对照研究。病例组由随后发生 ROP 的早产儿组成。对照组由在随访期间未发生 ROP 的胎龄匹配和性别匹配的早产儿组成。对病例组和对照组之间涉及患者人口统计和母亲特征的危险因素进行了比较。本研究共纳入 144 例患者（病例组 72 例，对照组 72 例）。在比较的 66 个可能的危险因素中，只有出生体重和产妇年龄被发现是显着的危险因素。病例组出生体重显着低于对照组（1,248.7±257.8 g vs. 1,335.5±297.2 g，P = 0.01），且与对照组相比，病例组产妇年龄显着较大（31.2±5.1岁 vs. 28.2±5.3岁，P < 0.001）。当母亲年龄 > 30 岁时，生出患有 ROP 的婴儿的优势比为 2.9。产妇年龄较大是新发现的早产儿发生 ROP 的危险因素。
To determine the risk factors, especially maternal risk factors, associated with the development of retinopathy of prematurity (ROP) in premature babies. A matched case–control study involving premature patients was undertaken retrospectively. The case group consisted of premature babies with the subsequent development of ROP. The control group consisted of gestational age-matched and sex-matched premature babies that did not develop ROP during the follow-up period. Risk factors involving patient demographics and maternal characteristics were compared between the case and control groups. A total of 144 patients were included in this study (72 patients in the case group and 72 patients in the control group). Among the 66 possible risk factors compared, only birth weight and maternal age were found to be significant risk factors. Birth weight was significantly lower in the case group (1,248.7 ± 257.8 g vs. 1,335.5 ± 297.2 g, P = 0.01), and maternal age was significantly older in the case group compared with that in the control group (31.2 ± 5.1 years vs. 28.2 ± 5.3 years, P < 0.001). The odds ratio of having babies with ROP was 2.9 when the maternal age was >30 years. Older maternal age is a newly identified risk factor for the development of ROP in premature babies.