MutS homologues hMSH4 and hMSH5: Diverse functional implications in humans
MutS homologues hMSH4 and hMSH5: Diverse functional implications in humans
复制标题
DOI：
10.2741/2112
复制
发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Tompkins, Joshua D.
中科院分区：
文献类型：
--
作者：
Her, Chengtao;Zhao, Nianxi;Tompkins, Joshua D.
DNA错配修复（MMR）途径是控制DNA复制过程中遗传信息忠实传递的最关键的基因组监测系统之一。MMR基因突变与遗传性非息肉病性结直肠癌之间的紧密联系部分反映了该途径在人类中的功能必要性。越来越多的证据表明，MMR蛋白广泛参与DNA代谢的各个方面，超出了DNA错配校正的范围，如DNA损伤反应和同源重组的过程。虽然目前缺乏证据表明hMSH4和hMSH5在MMR中的潜在功能参与，但这两种蛋白被认为在人类细胞减数分裂和有丝分裂DNA双链断裂（DSB）修复和DNA损伤反应中发挥作用。
The DNA mismatch repair (MMR) pathway is one of the most critical genome surveillance systems for governing faithful transmission of genetic information during DNA replication. The functional necessity of this pathway in humans is partially reflected by the tight link between MMR gene mutations and the development of hereditary nonpolyposis colorectal cancer. Increasing evidence has suggested a broad involvement of MMR proteins in various aspects of DNA metabolism beyond the scope of DNA mismatch correction, such as in the processes of DNA damage response and homologous recombination. Though evidence is presently lacking for potential functional involvement of hMSH4 and hMSH5 in MMR, these two proteins are thought to play roles in meiotic and mitotic DNA double strand break (DSB) repair and DNA damage responses in human cells.