A Drug-Perfluorocarbon Nanoemulsion with an Ultrathin Silica Coating for the Synergistic Effect of Chemotherapy and Ablation by High-Intensity Focused Ultrasound
A Drug-Perfluorocarbon Nanoemulsion with an Ultrathin Silica Coating for the Synergistic Effect of Chemotherapy and Ablation by High-Intensity Focused Ultrasound
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具有超薄二氧化硅涂层的药物-全氟化碳纳米乳剂，用于高强度聚焦超声化疗和消融的协同作用
DOI：
10.1002/adma.201402969
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发表时间：
2014-11-19
影响因子：
29.4
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Ma, Ming;Xu, Huixiong;Shi, Jianlin
利用一种新型的给药系统，实现了高强度聚焦超声（HIFU）化疗和消融的协同效应。该系统包括一个超薄的二氧化硅外壳，包裹着一个含有药物（CPT）和全氟碳（PFOB）的聚乳酸-羟基乙酸纳米乳核心。该纳米系统具有结构稳定性好、载药能力强、hifu介导药物快速释放等优点。
The synergistic effect of chemotherapy and ablation using high-intensity focused ultrasound (HIFU) is realized with a newly developed drug-delivery system. The system comprises an ultrathin silica shell surrounding a poly(lactic-co-glycolic acid) nanoemulsion core containing the drug (CPT) and a perfluorocarbon (PFOB). This nanosystem presents many advantages in drug delivery, such as excellent structural stability, high drug-loading capacity, and rapid HIFU-mediated drug release.