Seroepidemiology of Helicobacter pylori infection in a population of Egyptian children.
Seroepidemiology of Helicobacter pylori infection in a population of Egyptian children.
复制标题
埃及儿童人群幽门螺杆菌感染的血清流行病学。
DOI：
10.1093/ije/29.5.928
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发表时间：
2000
影响因子：
7.7
通讯作者：
Clemens,JD
中科院分区：
文献类型：
--
作者：
Naficy,AB;Frenck,RW;Abu-Elyazeed,R;Kim,Y;Rao,MR;Savarino,SJ;Wierzba,TF;Hall,E;Clemens,JD
BackgroundTo描述幽门螺杆菌感染的血清流行病学在人口中的埃及儿童3 years.MethodsA队列的儿童36个月以下，居住在阿布霍莫斯，埃及，每周两次在家里访问。获得了有关儿童母乳喂养状况的信息，并定期进行人体测量和家庭卫生调查。1997年6月，对187名6个月以上的研究参与者进行了血清调查。1997年10月再次进行了血清调查。所有血清均检测抗H IgG抗体。结果6月份H.幽门螺杆菌感染率为10%，其中6 ~ 10月感染率为15%。在6月至10月期间，19名儿童中有8名（42%）为H阳性。幽门感染血清学转为阴性。所有血清逆转发生在6-17个月的儿童中。除年龄外，没有社会人口或环境因素与事件H显着相关。幽门感染有和没有患病H的儿童之间的年龄别体重、身高别体重和年龄别身高z分数没有显著差异。结论H.幽门螺杆菌在埃及3岁以下儿童中很常见，与营养不良无关。没有预测H。幽门螺杆菌感染。需要在前瞻性队列研究中证实幼儿中的幽门螺杆菌感染，并且应该寻找持续感染的预测因子，因为只有这些可能与已知的感染后遗症相关。
BackgroundTo describe the seroepidemiology ofHelicobacter pyloriinfection in a population of Egyptian children under 3 years.MethodsA cohort of children under 36 months, residing in Abu Homos, Egypt, were visited at home twice weekly. Information regarding the child's breastfeeding status was obtained, and periodic anthropometric and household hygiene surveys were performed. In June 1997, a serosurvey was conducted on 187 study participants over 6 months old. The serosurvey was repeated in October 1997. All sera were tested for IgG antibodies toH. pylori.ResultsThe June prevalence ofH. pyloriinfection was 10%, and the incidence from June to October was 15%. Between June and October, 8 (42%) of 19 children that were positive forH. pyloriinfection seroreverted to negative. All seroreversions occurred in children 6–17 months. Other than age, no sociodemographic or environmental factor was significantly associated with incidentH. pyloriinfection. There was no significant differences in the weight-for-age, weight-for-height, and height-for-age z-scores between children with and without prevalentH. pyloriinfection.ConclusionsInfection withH. pyloriis common in Egyptian children under 3 years old and is not associated with malnutrition. No predictors forH. pyloriinfection were found. Our preliminary evidence for transientH. pyloriinfections in young children needs to be confirmed in a prospective cohort study, and predictors for persistent infection should be sought, since only these may be relevant to the known sequellae of infection.