ROLE OF THIOL COMPOUNDS IN MAMMALIAN MELANIN PIGMENTATION .2. GLUTATHIONE AND RELATED ENZYMATIC-ACTIVITIES
ROLE OF THIOL COMPOUNDS IN MAMMALIAN MELANIN PIGMENTATION .2. GLUTATHIONE AND RELATED ENZYMATIC-ACTIVITIES
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DOI：
10.1111/1523-1747.ep12530631
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发表时间：
1982-01-01
影响因子：
6.5
通讯作者：
THIVOLET, J
中科院分区：
文献类型：
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作者：
BENEDETTO, JP;ORTONNE, JP;THIVOLET, J
除酪氨酸酶外，谷胱甘肽还原酶可能在黑素细胞生物合成活性的调控中起重要作用。对哺乳动物进行了研究，呈现出被毛色素沉着的明确的基因型，突变小鼠[亚系C57 BL（6 J）]，即分别显示出纯均匀真黑素和褐黑素色素沉着的九色黑色（a/a）突变体和黄色（Ay/a）突变体。巯基化合物和谷胱甘肽相关的酶水平在小鼠皮肤的分析得出了类似的结果，在龟甲豚鼠皮肤。在黑色和黄色（或红色）皮肤之间观察到的谷胱甘肽和谷胱甘肽相关酶含量的差异提供了证据，即黑素细胞环境中谷胱甘肽还原酶活性的增加可能刺激色素细胞产生褐黑素而不是真黑素色素。
In addition to tyrosinase, glutathione-reductase may play an important role in the regulation and control of the biosynthetic activity of melanocytes. Studies were done on mammals, presenting a well-defined genotype for coat pigmentation, the mutant mouse [sub-line C57 BL (6J)], namely the nonagouti black (a/a) mutant and the yellow (Ay/a) mutant showing, respectively, pure uniform eumelanin and pheomelanin pigmentation. Analysis of thiol compounds and glutathione-related enzyme levels in mouse skin gave similar results to those found in tortoiseshell guinea pig skin. The observed differences in the glutathione and glutathione-related enzyme content between black and yellow (or red) skin provide evidence that the increase of glutathione-reductase activity in the environment of the melanocytes may stimulate the pigment cells to produce phaeomelanin instead of eumelanin pigment.