Add-on effects of a low-dose aripiprazole in resolving hyperprolactinemia induced by risperidone or paliperidone
Add-on effects of a low-dose aripiprazole in resolving hyperprolactinemia induced by risperidone or paliperidone
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DOI：
10.1016/j.psychres.2015.12.033
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发表时间：
2016-03-30
影响因子：
11.3
通讯作者：
Sheng, Jianhua
中科院分区：
文献类型：
--
作者：
Qiao, Ying;Yang, Fuzhong;Sheng, Jianhua
本研究探讨了低剂量阿立哌唑连续治疗对中国汉族女性精神分裂症患者中利培酮或帕利哌酮诱导的高泌乳素血症的影响。利培酮或帕利哌酮治疗4周后，66例患者中有60例明显改善并出现高泌乳素血症。随机分为治疗组（阿立哌唑连续治疗）和对照组（非连续治疗）各30例。在8周研究期间，维持利培酮和帕利哌酮的剂量;阿立哌唑维持在5 mg/天。第8周末治疗组催乳素水平显著低于对照组。治疗组和对照组在第8周末和第4周末雌二醇水平与血清催乳素水平呈负相关。在8周的研究期间，两组的阳性和阴性症状量表评分均显著改善。两组治疗后出现的不良事件发生率相似。小剂量阿立哌唑连续治疗可有效缓解女性精神分裂症患者利培酮和帕利哌酮引起的高泌乳素血症，且不会增加不良事件。(C)由Elsevier爱尔兰Ltd.出版
This study investigated the effects of a low-dose aripiprazole adjunctive treatment for risperidone- or paliperidone-induced hyperprolactinemia in Han Chinese women with schizophrenia. After 4 weeks of risperidone or paliperidone treatment, 60 out of 66 patients improved significantly and experienced hyperprolactinemia. They were randomly assigned to the treatment group (aripiprazole adjunctive treatment) (n=30) or control group (non-adjunctive treatment) (n=30). The dosage of risperidone and paliperidone were maintained; and aripiprazole was maintained at 5 mg/day during the 8-week study period. The prolactin levels at the end of the 8th week were significantly lower in the treatment group than in the control group. The estradiol level correlated negatively with serum prolactin level both in the treatment group and the control group at the end of the 8th week and the 4th week respectively. The Positive and Negative Syndrome Scale score improved significantly during the 8-week study period in both groups. The incidence of treatment-emergent adverse event was similar in two groups. Low-dose aripiprazole adjunctive treatment is effective in relieving risperidone- and paliperidone-induced hyperprolactinemia in female schizophrenic patients without increasing adverse event. (C) 2016 Published by Elsevier Ireland Ltd.